Forsite Diagnostics Limited

Molecular Vision Limited

Neeraj Adsul

Gihan Ryu

Gordon Jowett

Marcin Tokarzewski

A method for reading a test region of an assay includes: capturing a plurality of images of an assay with an imaging device; from each image of the plurality of images, extracting a region of interest comprising pixels of the image associated with a test region of the assay; from each extracted region of interest, estimating respective intensity values of at least a portion of the pixels; grouping the estimated intensity values into one or more clusters, said grouping comprising determining a total number of intensity values grouped into each cluster and a variance of each cluster; selecting the cluster having a total number of intensity values at or above a predetermined threshold and a smallest variance; calculating a mean intensity value of the selected cluster; and outputting the calculated mean intensity value as a result of the assay.

Assay reading method

A computer implemented method for reading a test region of an assay, the method comprising: (i) providing digital image data of a first assay; (ii) inputting the digital image data into a trained convolutional neural network configured to output a first probability, based on the input digital image data, that a first region of pixels of the digital image data corresponds to a first test region of the assay; (iii) if the first probability is at or above a first predetermined threshold, accepting the first region of pixels as a first region of interest associated with the first test region; and (iv) estimating an intensity value of a portion of the first test region in the first region of interest.

An optical device for the quantitative determination of the concentration of at least one analyte in a liquid sample comprises a housing () defining a first chamber () and a second chamber (). A sample port () is defined in the first chamber (). The sample port () receives light from a plurality of test regions of an assay device when the optical device is engaged with the assay device. The optical device further comprises a plurality of optical detectors () provided in the second chamber () and a mask member () interposed between the first chamber () and the second chamber () and having an aperture () defined therein and configured to direct light from the sample port () onto the optical detectors ().

Optical device for quantitative determination of the concentration of an analyte in a liquid sample comprising a mask member between first and second chambers

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York, United Kingdom

Neeraj Adsul