Ranbaxy Laboratories, Inc.

Neera Tiwari

Yatendra Kumar

Jag Mohan Khanna

Rakesh Kumar Arora

Shailendra Kumar Singh

Mohan Prasad

Hashim Nizar Poovanathil Nagoor Meeran

Subhash Dhar

Arun Malhotra

Prashant Kumar Sharma

Bhupendra Vashishta

Vinod George

Shailendra K Singh

The present invention relates to a process for the preparation of pure meropenem trihydrate.

Process for the preparation of pure meropenem trihydrate

The present invention relates to a process for the preparation of sterile doripenem.

Process for the preparation of sterile doripenem

A process for converting cephalosporin p-nitrobenzyl ester (Formula I) to the corresponding cephalosporin free acid (Formula II) comprising treating the cephalosporin p-nitrobenzyl ester with a metal selected from the group consisting of iron, magnesium, aluminum, and tin, and with hydrochloric acid in a mixture of water and a water-miscible organic solvent. Preferably, the metal is iron in the form of a fine powder, and the reaction is carried out at a temperature in the range of 30.degree.-50.degree. C.

Process for P-nitrobenzyl ester cleavage in cephalosporin

A process for the manufacture of 7-acylamino-3-hydroxycephem-4-carboxylate-1-oxide in E-rotamer form (Formula III), comprises reacting a 7-acylamino-3-exomethylenecepham-4-carboxylate-1-oxide with ozone in an inert organic solvent in the presence of a catalytic amount of an organic or inorganic base at a temperature ranging from about -80.degree. C. to about +20.degree. C. The E-rotamer (wherein the 3-hydroxy group is strongly hydrogen bonded to the carbonyl of the 4-ester group) exhibits different chemical and physical properties from and is more thermodynamically stable than, the Z-rotamer (wherein there is no hydrogen bonding between the 3-hydroxy group and the carbonyl of the 4-ester group).

Process for preparing Z and E-rotamers of 3-hydroxy cephem derivatives

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Gurgaon, India

Neera Tiwari