Genetics Institute, Inc.

Neelu Kaila

Jasbir S Seehra

Jean E Bemis

Yibin Xiang

John C McKew

Frank Eldridge Lovering

Lihren Chen

Novel compounds are disclosed which inhibit the activity of phospholipase enzymes in a mammal, particularly cytosolic phospholipase A. Pharmaceutical compositions comprising such compounds and methods of treatment using such compositions are also disclosed.

Inhibitors of phospholipase enzymes

Novel compounds are disclosed which inhibit the activity of phospholipase enzymes, particularly cytosolic phospholipase A . Pharmaceutical compositions comprising such compounds and methods of treatment using such compositions are also disclosed.

This invention provides substituted indole and indoline compounds useful in inhibiting phospholipase activity, particularly including cytosolic phospholipase A2 (cPLA2) activity, as well as pharmaceutical compositions containing the compounds and methods of using them to treat various maladies, including pain and inflammatory conditions.

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Natick, MA, United States of America

Neelu Kaila