Other

Merck + Co., Inc.

Merck Sharp + Dohme Corp.

Isis Pharmaceuticals, Inc.

Ionis Pharmaceuticals, Inc.

Neelima Bhat

Phillip Dan Cook

Thazha P Prakash

Balkrishen Bhat

David Brian Olsen

Malcolm Maccoss

Haoyun An

Marija Prhavc

Anne Bettina Eldrup

Quanlai Song

Steven S Carroll

Lawrence C Kuo

Robert L Lafemina

Anne B Eldrup

Amy L Himmelberger

Philip Dan Cook

The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention.

Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase

Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase of hepatitis C virus

Growing community of inventors

Carlsbad, CA, United States of America

Neelima Bhat