Council of Scientific and Industrial Research

Neelam Singh Sangwan

Avdhesh Kumar Srivastava

Sushil Kumar

Ghulam Nabi Qazi

Rakesh Tuli

Krishan Avtar Suri

Anil Kumar Dwivedi

Rajender Singh Sangwan

Bali Ram Tyagi

Ritu Trivedi

Prabhat Ranjan Mishra

Srikanta Kumar Rath

Divya Singh

Avinash Kumar

Girish Chandra Uniyal

Dharmendra Choudhary

Jyoti Gautam

Vikram Khedgikar

Jiaur Rahaman Gayen

Usha Yadav

Sulekha Adhikary

Rakesh Shukla

Narayan Das Chaurasiya

Anirudha Karvande

Laxmi Narayan Misra

Ashwni Verma

Payare Lal

Priyanka Kushwaha

Shweta Sharma

Prabodh K Trivedi

Kiran Khandelwal

Smrati Bhaduaria

Suresh Pratap Singh Gaur

Vivek Vidyadhar Bhosale

Hafsa Ahmad

Sharad Sharma

Sarika

A method for prevention and/or treatment of diminution of bone tissue using a composition comprising a compound selected from Withaferin A (WFA), Withanolide A, and Withanone. The composition showed enhanced WFA bioavailability in rodents against plain WFA, promotes bone marrow cell differentiation, and increases the percent of bone volume to tissue volume (BV/TV %) by 3 folds as compared to free Withaferin A (WFA).

Pharmaceutical composition for the treatment of diminution of bone tissue

The present invention relates to an improved process of analytical and quantitative isolation of withaferin-A from(Sanskrit: Ashwagandha, English: winter cherry) and other plants and products therefrom, said method comprising steps of selecting most appropriate extraction medium composition, with extraction solvent system consisting of a defined admixture of water and alcohol in a range of proportion of alcohol within a narrow range of (methanol, ethanol etc.) (preferably 60% alcohol and 40% water) for the dry plant material and from 60% to 80% alcohol in the alcohol-water mixture for fresh plant material, the invented extractant composition leading to better/improved yields and accurate quantitative estimations of withaferin A existent in planta or in materia, selecting effective state of the tissue particularly use of the fresh materials improving yields, providing logistic benefits of isolations and diagnosis, and according several other advantages including technological, economic, preventing contaminations etc., the said method being valuable and advantageous for standardization of botanicals, metabolomic characterization of plants particularly chemotypes, analyzing metabolic transitions under physiological, genetical, environmental and biotic perturbations.

Process for isolation of withaferin-A from plant materials and products therefrom

The present invention relates to a method for profiling of protein extract from hyper-acidic aerial parts of plant Scented Geranium (sp.), said method comprising steps of selecting effective extraction medium, with extraction medium consisting of 0.2 M sodium carbonate increasing percentage extract by about 600%, selecting effective medium to determine polypeptide pattern in said extract, with polypeptide pattern medium consisting of Sodium Carbonate ranging between 0.2 to 0.4 M, and 0.2 M Sodium Carbonate along with 50% dimethylsulfoxide, selecting effective media to determine enzyme multimolecular forms in said extract, with enzyme multimolecular forms media consisting of 0.2 M Tris-HCl buffer at pH 7.5, and optionally 50% dimethylsulfoxide; Sodium Carbonate at concentration ranging between 0.2 to 0.4 M and optionally 50% dimethylsulfoxide, and using biochemical and biophysical techniques comprising gel electrophoresis, spectrophotometry, centrifugation, protein estimation in said method to determine quantitative, qualitative, structural and functional facets of the proteins from said extract, and extraction compositions thereof.

Protein profiling of hyper acidic plants and high protein extraction compositions thereof

The invention provides a process for the induction of normal rooting on nodal and internodal stem segments without using hormones and/or other chemical treatments in Mentha species, which comprises oblique excision of shoots of Mentha species from the plants, immediately dipping the cut end of twigs or stems into water and keeping in complete dark for up to one week with by varying the temperature cycle for each set of 24 hours duration of the treatment.

Process for the induction of normal roots on nodes and internodes of stem segments without using hormone and/or chemical treatments in mentha species

The present invention provides a novel ecological method of phyto-remediation of alkaline ad chemically degraded soils, said method comprising the steps of dispersing biomass obtained from Pelargonium sp. in alkaline or chemically degraded soil.

Ecological method of phyto-remediation of alkaline and chemically degraded soils using scented geranium (Pelargonium sp.)

Growing community of inventors

Lucknow, India

Neelam Singh Sangwan