Vanderbilt University

Ned A Porter

Olivier Boutaud

L Jackson Roberts, Ii

John A Oates

Richard Caprioli

Jeremy L Norris

Douglas S Masterson

Huiyong Yin

Methods and compounds for the treatment or prevention of oxidative damage in a mammalian subject. The treatment and/or prevention may be on inhibiting heme-induced lipid peroxidation. Also discloses are methods and compounds for treating or preventing isoprostane-mediated tissue damage.

Inhibitors of hemeprotein-catalyzed lipid peroxidation

Compounds, compositions and methods related to the prevention or treatment of isoprostane-mediated tissue damage in a mammalian subject in need thereof.

The present invention includes a cleavable surfactant/detergent compound of the following formula: wherein the variables are defined herein. Embodiments of the cleavable surfactant/detergent compound are useful, for example, in methods for isolating a hydrophobic molecule that include providing a plasma comprising a hydrophobic molecule, applying the cleavable surfactant to the plasma so that the surfactant engages the hydrophobic molecule, cleaving the surfactant from the hydrophobic molecule, and analyzing said hydrophobic molecule.

Cleavable surfactants and methods of use thereof

A method of modifying protein samples that comprises combining the sample with a peroxycarbonate solution and inserting the sample into a mass spectrometer. The present invention also includes methods of N-terminus characterization.

MS based peptide and protein sequencing via reactions of lysine residues with peroxycarbonate compounds

Cleavable compositions and methods of use especially in MALDI MS analysis of hydrophobic proteins.

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Franklin, TN, United States of America

Ned A Porter