Baxter International Inc.

Baxter Healthcare Sa

Baxalta Gmbh

Takeda Pharmaceutical Company Limited

Nebojsa Nikolic

Hans-Peter Schwarz

Wolfgang Teschner

Azra Pljevljakovic

Harald Arno Butterweck

Kurt Schnecker

Theresa Friederike Bauer

Bernhard Koelbl

Klaus Tschetschkowitsch

Johanna Kindermann

Gerhard Poelsler

Michaela Frey

Wolfgang Grabmayer

Thomas Jancik

Matthias Fried

Barbara Riegler

Alma Kasapovic

The present invention relates to a new and improved method for preparing a highly concentrated immunoglobulin composition from pooled plasma for subcutaneous injection. A composition comprising 20% or more immunoglobulin suitable for subcutaneous use is also described.

Method to produce a highly concentrated immunoglobulin preparation for subcutaneous use

A method is disclosed for filtering a protein in a liquid mixture in a manner that does not substantially damage or otherwise limit the recovery of the protein in the filtration filtrate. The method generally includes passing a liquid mixture containing a protein (e.g., an aqueous vWF mixture) through a filter while applying a counter pressure to the liquid mixture filtrate to accurately reduce and control the pressure differential across the filter. The disclosed method has the advantage that relatively high filtration flow rates can be achieved at relatively low pressure differentials, in contrast to high pressure differentials, which actually reduce the filtration flow rate of protein liquid mixtures. Further, the method can recover substantially all of the protein that is initially present in the liquid mixture.

Counter-pressure filtration of proteins

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Vienna, Austria

Nebojsa Nikolic