Smithkline Beecham Corporation

Hoffmann-la Roche Inc.

Neal Ward

Victor Witold Jacewicz

Andrew Simon Craig

Vance J Novack

John Christopher Hanson

Deirdre O'Keeffe

David Alan Jones

Alan David Jones

Paroxetine is adsorbed on a carrier to form a free-flowing powder useful for capsule filling or for tablet formulation; and used in therapy to treat depression.

Paroxetine compositions

A process for preparing granisetron by cyclising a compound of structure (2).

Process for the preparation of granisetron

Compounds of structure (2) are prepared by reaction of an arecoline analogue of structure(4) with an organometallic compound containing an X-substituted phenyl group, such as a compound of structure (3).

Process for making paroxetine

Invented are methods of treatment using novel forms of paroxetine hydrochloride anhydrate.

Paroxetine hydrochloride form A or C

'Paroxetine hydrochloride (I) anhydrate free of bound propan-2-ol, and various forms thereof, are useful in the treatment of depression and other disorders for which administration of selective serotonin reuptake inhibitors are indicated.'

Paroxetine hydrochloride form A

Piperidine compounds, processes for preparing them, pharmaceutical compositions comprising them and their use in therapy are disclosed.

Paroxetine derivatives

'Paroxetine hydrochloride (I) anhydrate ##STR1## free of bound propan-2-ol, and various forms thereof, are useful in the treatment of depression and other disorders for which administration of selective serotonin reuptake inhibitors are indicated.'

Form of paroxetine hydrochloride anhydrate

The present invention relates to paroxetine hydrochloride anhydrate substantially free of bound propan-2-ol, several forms of the above, processes for preparing the above, new intermediates useful in preparing the above and methods of treating and/or preventing certain diseases by administering the compounds of the invention to a patient in need thereof.

Growing community of inventors

Crowborough, United Kingdom

Neal Ward