Abbott Laboratories Corporation

Neal T Sleszynski

Patrick P Fritchie

David Charles Arnquist

Gregory E Gardner

Cass J Grandone

Chadwick M Dunn

James T Holen

Robert C Gray

Jack F Ramsey

Jimmy D McCoy

Richard C East

Adrian John Murray

Grady Barnes, Iii

David W Murray

Robert Paul Luoma, Ii

Charles Michael Galitz

James E Mitchell

Julius J Toth

Richard D Button

Timothy P Henning

Thomas G Schapira

David Dean Cunningham

R Hayes Helgren

James F Mitchell

Kenneth S Johnson

Jill M Geist

Laura S Morici

Susan B Brontman

The embodiments disclosed relate to determination of an item of interest in a sample. One embodiment relates to a structure which comprises a process path. The process path comprises a process lane including a process step performance lane where a process step is performed, and a process step avoidance lane where the process step is avoided. A first prime mover is operatively connected with the process path for moving a container holding the sample along the process path. A first pipetting system is operatively associated with the process path for introducing the sample to the container. A second pipetting system is operatively associated with the process path for introducing a reagent to the container. A device is operatively connected with the process path and is selectively engagable with the container for mixing the sample and the reagent in the container. A second prime mover is operatively connected with the process path for selectively positioning the container in a selected one of the process step performance lane and the process step avoidance lane. A reader is operatively connected with the process path for determining the item of interest in the sample based upon a reaction between the sample and the reagent.

Structure for determination of item of interest in a sample

The embodiments disclosed relate to determination of an item of interest in a sample. In one method, a process path comprising a process lane including a process step performance lane where a process step is performed, and a process step avoidance lane where the process step is avoided is provided. A container holding the sample is moved along the process path. The sample is introduced to the container. A reagent is introduced to the container. The sample and the reagent are mixed in the container. The container is selectively positioned in a selected one of the process step performance lane and the process step avoidance lane. The item of interest in the sample is determined based upon a reaction between the sample and the reagent.

Method for determination of item of interest in a sample

Embodiments described herein provide methods of performing a process for determining an item of interest in a sample. In one embodiment, a container for holding the sample is accepted in a process lane where a process step is selectively automatically performed on the sample in the container. The process step is selectively automatically performed on the sample in the container. An effective length of the process lane is maintained constant while a physical length of the process lane is selectively varied.

Method of performing a process for determining an item of interest in a

A sensor for measuring the concentration of an analyte in a solution is disclosed. The sensor may be adapted for use as either an amperometric or a potentiometric sensor. It includes a membrane having a biologically active protein immobilized within. The membrane is attached and reliably sealed to a housing by means of ultrasonic welding, either directly or indirectly. Further, the membrane may be compressed to a fraction of its original dimensions. Metallic parts of the device may, optionally, be physically isolated from the sample solution to reduce corrosion. These features operate synergistically so that the claimed device exhibits relatively fast response and recovery times, is reliably leak-proof, and may be constructed in relatively small sizes.

Biosensor with a membrane containing biologically active material

Growing community of inventors

Kenosha, WI, United States of America

Neal T Sleszynski