Harbor Branch Oceanographic Institution, Inc.

Neal S Burres

Sarath P Gunasekera

Amy E Wright

Ross E Longley

Sue S Cross

Frank Koehn

Malika Gunasekera

Gabriel G Saucy

Yoel Kashman

Glynn Thomas Faircloth

Peter J McCarthy

May S Lui

Winnie C Thompson

H Howard Sun

Shinichi Sakemi

Richard D Wood

Amy S Wright

Steve Coval

Ranjit C Desai

Geewananda P Gunawardana

Novel terpene hydroquinones have been isolated from the marine sponge Strongylophora hartmanii. These compounds have been found to have antiviral and anti-leukemia activity. Thus, these compounds, and derivatives thereof, can be used to treat human and animal leukemia as well as viral infections. Additionally, the subject invention concerns the discovery that the terpene hydroquinone known as aureol has strong antiviral activity.

Novel antiviral and anti-leukemia terpene hydroquinones and methods of

This invention relates to the methods for the synthesis and use of acetylenic carbinols and their analogs, having various immunomodulatory properties in vitro and in vivo.

Synthesis of compounds with biological activity, and methods of use

Novel terpene hydroquinones have been isolated from the marine sponge Stronglophora hartmanii. These compounds have been found to have antiviral activity. Thus, these compounds, and derivatives thereof, can be used to treat viral infections. Additionally, the subject invention concerns the discovery that the terpene hydroquinone known as aureol has strong antiviral activity.

Novel antiviral terpene hydroquinones and methods of use

Novel acetylenic alcohols were isolated from the known marine sponge Cribrochalina vasculum. These compounds, and derivatives thereof, are useful agents for the treatment of cancers of humans and animals. Also, these compounds and their derivatives can be used as immunosuppressive agents for humans and animals.

Bioactive metabolites from cribrochalina vasculum

Novel terpene hydroquinones have been isolated from the marine sponge Strongylophora hartmanii. These compounds have been found to have antiviral and antitumor activity. Thus, these compounds, and derivatives thereof, can be used to treat human and animal tumors as well as viral infections. Additionally, the subject invention concerns the discovery that the terpene hydroquinone known as aureol has strong antiviral activity.

Novel antiviral and antitumor terpene hydroquinones and methods of use

Novel lactone compounds having remarkable immunomodulatory and antitumor activities, pharmaceutical compositions comprising such compounds, methods for the preparation of the novel compounds and compositions and methods of their use for therapeutic purposes are described. The new lactone compounds have the structure according to the formula: ##STR1## wherein: R=--H, --A, --CH.sub.2 --Q, --COA or --COZ,

Discodermolide compounds, compositions containing same and method of

Novel brominated bisindole-imidazole alkaloids have been isolated from marine sponges. These compounds, and derivatives thereof, are useful antimicrobial and antitumor compounds.

Bis-indole imidazole compounds which are useful antitumor and

Discodermolide compounds, compositions containing same and methods of

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Highland Park, IL, United States of America

Neal S Burres