Dow Global Technolgoies LLC

Hoechst Marion Roussel

Neal J Fetner

Jin Zhao

David L Malotky

Matthias Knarr

Roland Adden

Meinolf Brackhagen

Dennis K Klipa

Michael J Devon

Roberto Gandolfi, Deceased

A process for producing an aqueous composition comprising a dispersed esterified cellulose ether comprises the steps of grinding, in the presence of an aqueous diluent an esterified cellulose ether comprising (i) groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOA, wherein R is a N divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, blending a salt of a fatty acid with the esterified cellulose ether and choosing the amounts of aqueous diluent, esterified cellulose ether and salt of a fatty acid that the produced aqueous composition comprises at least 20 percent of the dispersed esterified cellulose ether and heating the aqueous composition to a temperature of from 37 to 80 C during or after the grinding step.

Process for producing dispersion of esterified cellulose ether

An aqueous composition useful for producing capsules shells comprises a) at least one dispersed esterified cellulose ether comprising (i) groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and b) from 0.05 to 20 percent of at least one salt of a fatty acid, based on the weight of the dispersed esterified cellulose ether, wherein the median particle size, d50, of the dispersed esterified cellulose ether particles is up to 7 micrometers, such median particle size (d50) being the size at which 50 mass percent of the particles have a smaller equivalent diameter and 50 mass percent have a larger equivalent diameter.

Dispersion comprising an esterified cellulose ether

An aqueous composition comprising at least 10 weight percent of a dispersed esterified cellulose ether, based on the total weight of the aqueous composition, wherein the esterified cellulose ether comprises (i) groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOH or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula &#x2014;C(O)&#x2014;R&#x2014;COOH, R being a divalent aliphatic or aromatic hydrocarbon group, and at least a part of the groups &#x2014;C(O)&#x2014;R&#x2014;COOH are neutralized with an ammonium salt of carbonic acid, formic acid or acetic acid, and wherein d90 of the dispersed esterified cellulose ether particles is up to 10 micrometers, d90 being the diameter where 90 mass percent of the particles have a smaller equivalent diameter and the other 10 mass percent have a larger equivalent diameter, is useful for preparing coating dosage forms including tablets, capsules and others, or for the formation of capsules shells.

Dispersion comprising a partially neutralized esterified cellulose ether

The present invention relates to a novel process for the preparation of 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanones from 1-halo-3-trialkylsilanyl-benzenes. 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanones are useful for the treatment of Alzheimer's disease and senile dementia. In addition, the present invention relates to a novel process for purifying 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanones utilizing a novel extraction method.

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Midland, MI, United States of America

Neal J Fetner