Flagship Pioneering Innovations V, Inc.

Evelo Biosciences, Inc.

Perseptive Biosystems Inc.

Neal Gordon

Geoffrey Von Maltzahn

David Arthur Berry

Noubar Boghos Afeyan

Johanne Kaplan

John Miles Milwid

Jacob Rosenblum Rubens

Shaila Rahman

Michael Travis Mee

Bo Zhang

Molly Krisann Gibson

Kyle Marvin Trudeau

Kiana Mahdaviani

Nathan Wilson Stebbins

Jagesh Vijaykumar Shah

Brigham Jay Hartley

Tamar Rose Putiri

Matthew Milnes Dobbin

The present disclosure provides, at least in part, methods and compositions for in vivo fusosome delivery. In some embodiments, the fusosome comprises a combination of elements that promote specificity for target cells, e.g., one or more of a fusogen, a positive target cell-specific regulatory element, and a non-target cell-specific regulatory element. In some embodiments, the fusosome comprises one or more modifications that decrease an immune response against the fusosome.

Fusosome compositions and uses thereof

In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.

Compositions for facilitating membrane fusion and uses thereof

Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial or fungal entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent transplant disorders, e.g., graft-versus-host disease (GVHD), in a subject are also provided.

Probiotic and prebiotic compositions, and methods of use thereof for treatment and prevention of graft versus host disease

The invention features an apparatus for the separation and analysis of proteins, which includes a sample input, a first liquid chromatography column, a multiport injection valve connecting the sample input to the column, a pump for providing variable pressure delivery of a solution to the column via the multiport valve, and a program for specifying a sequence of system control programs.

Protein chromatography system

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Brookline, MA, United States of America

Neal Gordon