Flagship Pioneering Innovations V, Inc.

Evelo Biosciences, Inc.

Perseptive Biosystems Inc.

Neal Gordon

John Miles Milwid

Jacob Rosenblum Rubens

Michael Travis Mee

Geoffrey Von Maltzahn

David Arthur Berry

Noubar Boghos Afeyan

Johanne Kaplan

Shaila Rahman

Kyle Marvin Trudeau

Brigham Jay Hartley

Jagesh Vijaykumar Shah

Bo Zhang

Nathan Wilson Stebbins

Molly Krisann Gibson

Kiana Mahdaviani

Tamar Rose Putiri

Matthew Milnes Dobbin

Geoffrey A Von Maltzahn

Fusosome compositions and methods are described herein.

Compositions and methods for compartment-specific cargo delivery

The present disclosure provides, at least in part, methods and compositions for in vivo fusosome delivery. In some embodiments, the fusosome comprises a combination of elements that promote specificity for target cells, e.g., one or more of a fusogen, a positive target cell-specific regulatory element, and a non-target cell-specific regulatory element. In some embodiments, the fusosome comprises one or more modifications that decrease an immune response against the fusosome.

Fusosome compositions and uses thereof

In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.

Compositions for facilitating membrane fusion and uses thereof

Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial or fungal entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent transplant disorders, e.g., graft-versus-host disease (GVHD), in a subject are also provided.

Probiotic and prebiotic compositions, and methods of use thereof for treatment and prevention of graft versus host disease

The invention features an apparatus for the separation and analysis of proteins, which includes a sample input, a first liquid chromatography column, a multiport injection valve connecting the sample input to the column, a pump for providing variable pressure delivery of a solution to the column via the multiport valve, and a program for specifying a sequence of system control programs.

Protein chromatography system

Growing community of inventors

Brookline, MA, United States of America

Neal Gordon