Merck + Co., Inc.

Neal C Connors

Thomas R Verhoeven

Michel M Chartrain

Roger C Olewinski, Jr

Paul J Reider

George M Garrity

Chris H Senanayake

F Edward Roberts

Brian Heimbuch

Jinyou Zhang

Randolph L Greasham

Francis P Gailliot

Barbara A Jackey

Chanyong Lee

Barry C Buckland

A process is disclosed that bioconverts indene to (1S)-amino-(2R)-indanol substantially free of any of its stereoisomers, by the action of a strain of P. putida or Rhodococcus sp., followed by various chemical step(s), e.g., chiral specific crystallization, treatment with strong acid in the presence of acetonitrile.

Conversion of indene to (1S)-amino-(2R)-indanol free of any

A process is disclosed that bioconverts indene to (1S)-amino-(2R)-indanol substantially free of any of its stereoisomers, by the action of the enzyme dioxygenase, followed by various chemical step(s), e.g., chiral specific crystallization, treatment with strong acid in the presence of acetonitrile.

Pseudomonas putida strain with dioxygenase activity

A process is disclosed that quantitatively bioconverts indene to (1S,2R)-indene oxide and (1S,2R)-indandiol, by the action of fungal haloperoxidase followed by various chemical step(s), e.g., adjusting the pH.

Quantitative conversion of indene to (1S,2R) indene oxide and

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Fanwood, NJ, United States of America

Neal C Connors