Cubist Pharmaceuticals, Incorporated

Althea Technologies, Inc.

Other

Amgen Inc.

Ajinomoto Althea, Inc.

Anjinomoto Althea, Inc.

Nazer Khalaf

Chandrika Govardhan

Dennis D Keith

Jan-Ji Lai

Reena J Patel

Bhami Shenoy

Margaret Ellen McGrath

Sibyl Baladi

Chanchal Randhawa

Chu W Jung

Twinkle R Christian

Christi L Clogston

William Callahan

Rahul Rajan Kaushik

Benjamin Simeone

Qahera Munaim

Alona Teran

Saraswathi Mandapati

Kirill Yakovlevsky

Michael Shamashkin

Chandrika P Govardhan

Benjamin Paul Simeone

Margaret Mcgrath

Mikhail Chamachkine

Described herein are therapeutic protein formulations comprising N-methyl pyrrolidone (NMP), methods related to reducing viscosity of pharmaceutical formulations and methods related to stabilizing pharmaceutical formulations using NMP.

Reduced viscosity protein pharmaceutical formulations

Described herein are anti-PCSK9 antibody crystals, methods of making such antibody crystals and formulations comprising the antibody crystals.

Crystalline antibody formulations

The present invention relates to stable, extended release crystals of human growth hormone or a human growth hormone derivative and compositions or formulations comprising such crystals. The invention further provides methods for producing those crystals and compositions. The invention further provides methods for treatment of an individual having disorders associated with human growth hormone deficiency or which are ameliorated by treatment with human growth hormone using those crystals and compositions or formulations.

Human growth hormone crystals and methods for preparing them

Protein A crystals and Protein A cross-linked protein crystals (CLPCs) are described. Methods of preparing and using are also disclosed.

Protein A crystals and cross-linked crystals and methods of use thereof

Protein a crystals and cross-linked crystals and methods of use thereof

The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.

Methods for preparing purified lipopeptides

This invention relates to SPPs, spherical nanocrystalline composite particles or crystalline SPPs of biologically active proteins or compositions, including formulations, comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs. More particularly, methods are provided for the production of SPPs, spherical nanocrystalline composite particles or crystalline SPPs of high concentrations of biologically active proteins, and for the preparation of stabilized SPPs, spherical nanocrystalline composite particles or crystalline SPPs for use alone, or in dry or slurry compositions. This invention also relates to methods for stabilization, storage and delivery of biologically active proteins using SPPs, spherical nanocrystalline composite particles or crystalline SPPs. The present invention further relates to methods using SPPs, spherical nanocrystalline composite particles or crystalline SPPs, or compositions or formulations comprising such SPPs, spherical nanocrystalline composite particles or crystalline SPPs, for biomedical applications, including biological delivery to humans and animals.

Spherical protein particles and methods for making and using them

Growing community of inventors

Worcester, MA, United States of America

Nazer Khalaf