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Dextran Products Limited

Natu Patel

Thomas C Usher

Chhagan G Tele

The present invention provides a process for the preparation of water soluble alkali metal salts of cellulose sulfate having a degree of substitution ranging from 1 to 3 and viscosity of 1 percent aqueous solution in excess of 20 centipoises (cps). The process involves the use of chlorosulfuric acid as a sulfonating agent in the presence of pyridine used as a solvent in reaction. The important steps of the process for preparation of the water soluble salts include presoaking of the cellulose in pyridine followed by washing the pyridine salt with an alcohol such as methanol and reacting saturated alkali metal bicarbonate or carbonate solutions with the sulfonated cellulose.

Process for preparing soluble alkali metal salts of cellulose sulfate

This invention relates to an improved process for the manufacture of diethylaminoethyl dextran (DEAE dextran) and the diethylaminoethyl derivative of hydrogenated dextran (DEAE hydrodextran). A product of greater purity and improved color is obtained by the addition of a borohydride, such as sodium borohydride during manufacture to generate hydrogen in situ during the reaction.

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Boca Raton, FL, United States of America

Natu Patel