Hisamitsu Pharmaceutical Company, Inc.

Natsumi Kase

Satoshi Amano

Tomohiro Shinoda

Tetsuro Tateishi

Sachiko Honma

Keita Mori

By providing a non-liquid drug reservoir layerhaving first and second principal surfaces and containing a drug and a polymer that is to be a base, a drug permeation layerdisposed at the first principal surface side of the drug reservoir layerand being lower in permeability of the drug than the drug reservoir layer, and a first backingwith a bending resistance of 10 to 80 mm that is formed so as to cover a side surface of the drug reservoir layer, skin irritation can be reduced.

Transdermal preparation

A transdermal absorption preparation having a support and a pressure-sensitive adhesive layer consisting of multiple layers, wherein the pressure-sensitive adhesive layer comprises a drug-retaining layer containing a drug and an acrylic pressure-sensitive adhesive and a skin adhesion layer containing a styrene-isoprene-styrene block copolymer. This preparation can continuously release bisoprolol at a constant concentration. Moreover, it can be easily produced.

Transdermal absorption preparation

Provided is a transdermal preparation, which is capable of long-term (1-day to 7-day) release of a basic drug from a preparation, continuously and at a consistent concentration; shows little reduction over time in the drug content, even if multiple drugs are contained in the preparation; and is produced by a simple process. The transdermal preparation comprises a substrate, and an adhesive layer containing a basic drug and a water-soluble polymer.

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Tsukuba, Japan

Natsumi Kase