Fujisawa Pharmaceutical Company, Ltd.

Astellas Pharma Gmbh

Ujisawa Pharmaceutical Co., Ltd.

Natsuko Kayakiri

Masashi Hashimoto

Masahiro Neya

Hirokazu Tanaka

Keiji Hemmi

Teruo Kyoto Oku

Kozo Sawada

Hitoshi Yamazaki

Naoki Fukami

Keisuke Imai

Satoshi Okada

Hiroshi Marusawa

Yuki Saitoh

Yoshio Kawai

Kentaro Sato

Hidenori Azami

Kousei Yoshihara

Yuki Sawada

Shigeki Satoh

Nobukiyo Konishi

Katsuya Nakamura

Takayuki Inoue

Shinji Shigenaga

Kazuo Okumura

Kazuhiko Take

Tsuyoshi Mizutani

Fumiyuki Shirai

Akio Kuroda

Masataka Morita

Yoshiteru Eikyu

Yasuharu Urano

Junya Ishida

Takumi Yatabe

Kazuo Nakai

Keiji Hemmi, Deceased

Noriko Yoshida

A compound of the formula (I): wherein Ris hydrogen or lower alkyl;

Pyrazole derivatives

This invention relates to piperazine derivatives of the formula: wherein each symbol is as defined in the description, and its pharmaceutically acceptable salt, to processes for preparation thereof, to pharmaceutical composition comprising the same, and to a use of the same for treating or preventing Tachykinin-mediated diseases in human being or animals.

Piperazine derivatives

A compound of formula (I) wherein A is a sulfonyl or a carbonyl; R is an optionally substituted aryl, an optionally substituted heterocyclic group, an optionally substituted lower alkyl or an optionally substituted lower alkenyl; R is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; R is an optionally substituted lower alkyl, an optionally substituted lower alkoxy, an optionally substituted aryloxy, an optionally substituted lower alkenyl, an optionally substituted aryl, an optionally substituted heterocyclic group or an optionally substituted amino; R is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; R5 is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; and R is a hydroxy or a protected hydroxy, and a pharmaceutically acceptable salt thereof. The compound of the present invention is useful as a medicament for prophylactic and therapeutic treatment of MMP-or TNF&agr;-medicated diseases.

Piperazine compounds as inhibitors of MMP or TNF

Anthranilic acid derivatives as inhibitors of the cGMP-phosphodiesterase

A compound of formula (I) wherein A is a sulfonyl or a carbonyl; R,is an optionally substituted aryl, an optionally substituted heterocyclic group, an optionally substituted lower alkyl or an optionally substituted lower alkenyl; R,is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; R,is an optionally substituted lower alkyl, an optionally substituted lower alkoxy, an optionally substituted aryloxy, an optionally substitued lower alkenyl, an optionally substituted aryl, an optionally substituted heterocyclic group or an optionally substitued amino; R,is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; R,is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; and R,is a hydroxy or a protected hydroxy, and a pharmaceutically acceptable salt thereof. The compound of the present invention is useful as a medicament for prophylactic and therapeutic treatment of MMP- or TNF&agr;-mediated diseases.

Quinoline compounds as H.sup.+ -ATPases

Peptide compounds, their preparation and uses

Benzofuran derivatives useful as inhibitors of bone resorption

Peptide compounds of the formula (I') ##STR1## in which R.sup.1 is acyl,

Peptide compound and its preparation

Endothelin antagonists and their preparation

A compound of the formula: ##STR1## wherein R.sup.1 is carboxy or pharmaceutically acceptable salts and esters thereof;

Indole derivatives

Indole derivatives of the following formula: ##STR1## wherein R.sup.1 is carboxy(lower)alkyl or protected carboxy(lower)alkyl,

A compound of the formula: ##STR1## wherein R.sup.1 is lower alkyl optionally substituted aryl; or amino optionally substituted; and

Amino acid derivatives, processes for the preparation thereof and

Indole derivatives of the formula ##STR1## and pharmaceutical compositions thereof. They are useful for treating or preventing testosterone 5-alpha-reductase-mediated diseases, such as alopecia, acnes and prostatism.

Indole derivatives and their use for testosterone

Growing community of inventors

Tsukuba, Japan

Natsuko Kayakiri