Vernalis Research Limited

Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Nathaniel Monck

David Reginald Adams

Howard Langham Mansell

Ian Anthony Cliffe

Jonathan Mark Bentley

Hans G Richter

Stephan Roever

Paul Hebeisen

Jonathan Richard Anthony Roffey

James Edward Paul Davidson

Richard John Hamlyn

Claire Elizabeth Dawson

Robert Mark Pratt

Robin Gerald Shepherd

Corinna Dagmar Bodkin

Wolfgang Guba

Suneel Gaur

Matthew Alexander James Duncton

Ashley Roger George

Jon Mark Bentley

David Bebbington

By Joy Miriam Shepherd

Vicki Ruston

The present invention refers to chemical compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein Rto Rhave the significance given in claim 1. These compounds can be used for the preparation of medicaments.

Tetracyclic 6 azapyrazinoindolines as 5HT2C receptor agonists for obesity

The present invention refers to chemical compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein Rto Rhave the significance given in claim. These compounds can be used for the preparation of medicaments.

Morpholine derivatives as 5HT2C receptor agonists for the treatment of obesity

A compound of formula (1) wherein R is aryl; and R is hydrogen or alkyl; pharmaceutically acceptable addition compounds thereof; and their use in therapy, particularly for the treatment and prophylaxis of CNS disorders such as anxiety and epilepsy.

Azetidinecarboxamide derivatives for treating CNS disorders

A chemical compound of formula (I) wherein: R and R are independently selected from hydrogen and alkyl; R is alkyl; R , R and R are independently selected from hydrogen, halogen, hydroxy, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsufoxyl, alkylsulfonyl, nitro, carbonitrile, carbo-alkoxy, carbo-aryloxy and carboxyl; R is selected from hydrogen, halogen, hydroxy, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsulfoxyl, alkylsulfonyl, nitro, carbonitrile, carbo-alkoxy, carbo-aryloxy and carboxyl; A is a 5- or 6-membered partially unsaturated or aromatic heterocyclic ring or a 5- or 6-membered partially unsaturated carbocyclic ring, wherein if A is a 6-membered partially unsaturated carbocyclic ring then at least one of R to R is other than hydrogen, and pharmaceutically acceptable salts, addition compounds and prodrugs thereof, and the use thereof in therapy, particularly as an agonist or antagonist of a 5HT receptor, particularly a 5HT receptor, for instance in the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinial disorders; diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity.

Indole derivatives process for their preparation, pharmaceutical compositions containing them and their medicinal application

Azetidinecarboxamide derivatives for the treatment of CNS disorders

Indoline derivatives as 5-HT2B and or 5-HTC receptor ligands

Growing community of inventors

Wokingham, United Kingdom

Nathaniel Monck