Pacific Biosciences of California, Inc.

Boston Scientific Scimed, Inc.

Sionyx, Inc.

Becton Dickinson and Company Limited

Embecta Corp.

Sionys, Inc.

Nathaniel McCaffrey

Stephen Wilson Turner

Ravi Saxena

Jason Sproul

Adrian Nielsen Fehr

Scott Edward Helgesen

James Edward Carey

Jane Bareau

Laura Keith

James McNally

Zhihua He

James R Petisce

Jeffrey Wegener

John Kummailil

Amit Uday Limaye

Martin U Pralle

Aaron Weber

Michael Yarger

Xia Li

Embodiments of the invention include an apparatus including an enclosure configured to receive an endoscope having an electromagnetic radiation sensor. The apparatus also includes an electromagnetic radiation source having at least a portion disposed within the enclosure. The electromagnetic radiation source is configured to emit electromagnetic radiation based on a calibration instruction. The electromagnetic radiation sensor is configured to receive at least a portion of the electromagnetic radiation when at least a portion of the endoscope is coupled to the enclosure.

Methods and apparatus for calibration of a sensor associated with an endoscope

A system and method is provided for a continuous glucose monitoring (CGM) system and the processing of data collected thereby. An internet gateway chip () is included in elements of a CGM system to facilitate direct data communication with cloud network storage () thereby communicate and store data of a CGM sensor () of the CGM system. The internet gateway chip can be included in a receiver (), such as an existing wireless receiver and display device of the CGM; in a smart phone or similar device, where the smart phone is also the wireless receiver and display device of the CGM; or in the sensor, such as an existing sensor and/or transmitter () of the CGM to facilitate direct data communication between the CGM system and cloud network storage.

Direct CGM connectivity to a cloud storage network

An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device. The illumination may be received from a top, a side edge, and a bottom of the device. The waveguide assembly may include a nanoscale aperture disposed in the substrate and extending through the cladding. The aperture defines a reaction cell for receiving a set of reactants. In various aspects, the device includes a sensor element and the illumination pathway is through the sensor element. Waveguides and illumination devices, such as plasmonic illumination devices, are also disclosed. Methods for forming and operating the devices are also disclosed.

Illumination of integrated analytical systems

A medical device such as a cannula, catheter, needle or biosensing probe includes an elongated body for penetrating, inserting and/or positioning in or through the skin of a patient. The elongated body has an outer surface that when positioned in the patient with a coefficient of friction sufficient to inhibit movement between the elongated body on the skin at the insertion site to inhibit irritation at the infusion site. A lubricious coating is provided on the elongated body to assist in penetration and/or insertion of the elongated body into the patient. The lubricious coating can be removed by a shearing action by the insertion of the elongated body into the patient and/or by absorption of the lubricious coating to expose the outer surface of the elongated member.

Device and method for inhibiting movement of a medical device in a patient

An analytical assembly within a unified device structure for integration into an analytical system. The analytical assembly is scalable and includes a plurality of analytical devices, each of which includes a reaction cell, an optical sensor, and at least one optical element positioned in optical communication with both the reaction cell and the sensor and which delivers optical signals from the cell to the sensor. Additional elements are optionally integrated into the analytical assembly. Methods for forming and operating the analytical system are also disclosed.

Integrated analytical system and method

The invention relates to devices and methods for nanopore sequencing. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS. The invention includes devices having sample and reference pores connecting sample, measurement and reference chambers, wherein potential measurements in each chamber is used to provide an accurate determination of current through a sample nanopore, improving nanopore sequencing.

Nanopore sequencing using ratiometric impedance

In one embodiment, an imaging method may include receiving an intensity value of a first spectral channel associated with a pixel location. The intensity value of the first spectral channel may be based on electromagnetic radiation reflected from an object after being emitted from a narrow-band electromagnetic radiation source. The method may further include defining an intensity value of a second spectral channel based on the intensity value of the first spectral channel. The second spectral channel may be associated with a spectral region of electromagnetic radiation different from a spectral region of electromagnetic radiation associated with the first spectral channel. The method may also include associating the intensity value of the second spectral channel with the pixel location.

Method and apparatus for wide-band imaging based on narrow-band image data

A method of calibrating an image sensor may include detecting a response from a pixel of the image sensor as a result of light having an intensity impinging on the pixel, and measuring the actual standard deviation of the response of the pixel at the intensity of light. The method may also include determining an averaging number for the pixel at the intensity. The averaging number may be a number of responses of the pixel at the intensity to be averaged to attain an average response having a standard deviation less than or equal to a target value. The method may further include determining the average response of the pixel using the determined averaging number.

Image sensor calibration

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Hampton Falls, NH, United States of America

Nathaniel McCaffrey