Northwestern University

University of Pittsburgh

U.S. Department of Energy

Nathaniel L Rosi

Chad A Mirkin

David A Giljohann

C Shad Thaxton

Andrea David Merg

Chun-Long Chen

Tao Li

SonBinh T Nguyen

David Luebke

Hunaid B Nulwala

Stephane Petoud

Erik Albenze

Ryan Vachon Thaner

Michael Lartey

Surendar R Venna

Soumitra Punekar

Kiley A White

Demetra Anne Chengelis Czegan

This disclosure related to modular and programmable peptide-oligonucleotide chimeras comprising of peptide and oligonucleotide segments interlinked by an organic core are presented and their assembly as morphologically-tunable soft materials, for example, nanostructure compositions comprising a plurality of compounds comprising a peptide segment and an oligonucleotide segment interlinked by an organic core moiety.

Peptide-oligonucleotide chimeras (POCs) as programmable biomolecular constructs for the assembly of morphologically-tunable soft materials

Described herein are metal nanoparticle superstructures and methods and compounds for making the same.

Single-helical gold nanoparticle superstructures and methods of making

An approach to synthesizing and assembling nanoparticles into discrete, size-tunable, pre-designed architectures is realized in a single synthetic/process step.

Templates for controlling synthesis of nanoparticles into discrete assemblies

Materials and methods for regulating gene expression using nanoparticles functionalized with antisense oligonucleotides are provided.

Nucleic acid functionalized nanoparticles for therapeutic applications

Nucleic acid functionalized nonoparticles for therapeutic applications

Mixed Matrix Membrane (MMM) are composite membranes for gas separation and comprising a quantity of inorganic filler particles, in particular metal organic framework (MOF), dispersed throughout a polymer matrix comprising one or more polymers. This disclosure is directed to MOF functionalized through addition of a pendant functional group to the MOF, in order to improve interaction with a surrounding polymer matrix in a MMM. The improved interaction aids in avoiding defects in the MMM due to incompatible interfaces between the polymer matrix and the MOF particle, in turn increasing the mechanical and gas separation properties of the MMM. The disclosure is also directed to a MMM incorporating the surface functionalized MOF.

Surface functionalization of metal organic frameworks for mixed matrix membranes

Metal-organic frameworks (MOFs) are crystalline porous materials that include metal ions linked together into periodic structures via organic ligands. MOFs that contain lanthanide ions are a new class of visible and near-IR luminescent materials, suitable for a broad range of applications. For example, the MOF framework afforded by 2,5-dimethoxy-1,4-phenylene)di-2,1-ethenediyl]bis-carboxylate is associated with unusually long luminescence lifetimes. Thus, a complex of this ligand with a lanthanide provides a sharp emission profile, coupled with a comparatively long signal lifetime, for an unusually high luminescence. More generally, lanthanide-MOF systems exhibit several advantages that are ideal for barcoded materials, due to the photophysical attributes of lanthanide cations and the well-defined organization of the MOF structure.

Lanthanide metal-organic frameworks and uses thereof

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Pittsburgh, PA, United States of America

Nathaniel L Rosi