Vernalis Research Limited

Other

Hoffmann-la Roche Inc.

Nathaniel Julius Thomas Monck

Roger John Gillespie

Jonathan Mark Bentley

Andrew James Bird

Hans G Richter

Stephan Roever

Paul Hebeisen

Sven Taylor

David Reginald Adams

Howard Langham Mansell

Jonathan Richard Anthony Roffey

James Edward Paul Davidson

Toby Jonathan Blench

Simon Edward Ward

The present invention relates to compounds of formula (I) as well as pharmaceutically acceptable salts, solvates and esters thereof. These compounds can be used to prepare pharmaceutical compositions for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes, obesity and sleep apnoea.

1,2,3,4,9,9a-hexahydro-2,4a,5-triaza-fluorene and 1,2,3,4-tetrahydro-2,4a,5-triaza-fluorene derivatives

The use of a compound of formula (1), as disclosed in the specification, wherein R , R , R , R , R and R are independently selected from hydrogen, alkyl and aryl, or pharmaceutically acceptable salts thereof, with the proviso that wherein R to R and R are hydrogen, R is not selected from CH CH NHSO CH , CH CH NHSO CF and methyl substituted by SO NH , SO H, PO H , CONHOH or a heterocyclic group selected from formulae (a), (b), (c), (d) and (e) in the manufacture of a medicament for use in the treatment of a condition generally associated with abnormalities in glutamatergic transmission.

2-adamantanemethanamine compounds for treating abnormalities in glutamatergic transmission

The present invention relates to indoline derivatives. These compounds are especially useful for the prevention and treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes, sleep apnea, and especially for the treatment and prevention of obesity.

Indoline derivatives and method of treating obesity

Adamantanecarboximidamide derivatives and their use as NMDA antagonists

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Wokingham, United Kingdom

Nathaniel Julius Thomas Monck