Merck + Co., Inc.

Nathaniel Grier

Richard A Dybas

Bruce E Witzel

Robert A Strelitz

Arthur F Wagner

Tsung-Ying Shen

David Penman Jacobus

Eugene L Dulaney

Arthur A Patchett

Elbert E Harris

Henry Joshua

Gunther W Kuron

Merwin F Hoover

Jesse W Huff

Bruce E Witzei

Tsung-Ting Shen

2,4-Disubstituted-1,2,5-thiadiazol-3(2H)-one antimicrobials have broad spectrum antibacterial and antifungal activity. They are found to be especially useful in agriculture to protect plants against diseases such as leaf, stem, and fruit spotting, internal discoloration and decay of fruits and vegetables. These compounds are particularly active against diseases caused by the genera Pseudomonas, Xanthomonas, Erwinia, and Corynebacterium.

2,4-Disubstituted-1,2,5-thiadiazol-3(2H)-one antimicrobials

Antimicrobial agents suitable for use in aqueous systems for their preservation against biodeterioration include substitutedpiperidinomethylpropenenitriles and propanenitriles. The unsaturated compounds are prepared by reaction of a suitable piperidine with cyano acetic acid and formaldehyde: the propane derivatives therefrom by nucleophilic addition.

2-(Substitutedpiperidylmethyl) propane nitriles and compositions thereof

Antimicrobial agents suitable for use in aqueous systems for their preservation against biodeterioration include substitutedpiperidinomethyl-propenenitriles and propanenitriles. The unsaturated compounds are prepared by reaction of a suitable piperidine with cyano acetic acid and formaldehyde: the propane derivatives therefrom by nucleophilic addition.

2-(Substituted piperidylmethyl) propene and propane nitriles

Antimicrobial agents suitable for use in aqueous systems for their prservation against biodeterioration include substitutedpiperidinomethylpropenenitriles and propanenitriles. The unsaturated compounds are prepared by reaction of a suitable piperidine with cyano acetic acid and formaledehyde: the propane derivatives therefrom by nucleophilic addition.

2-(Substitutedpiperidylmethyl) propene and propane nitriles

Novel halophenyl and loweralkyl substituted halophenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like.

Polyamine compounds as antibacterial agents

4-Amino- and 2,4-diaminopyrimidines with a quaternized ring nitrogen and an oxygen bearing substituent such as hydroxyalkyl, alkoxyalkyl, or alkanoyl on one of the exo- or endocyclic nitrogens and a C.sub.6-18 alkyl on another, are highly active antimicrobial agents with a relatively low acute mammalian toxicity.

Antimicrobial aminopyrimidinium salts

2-Substituted-aminopropene and propanenitriles of the formula: ##STR1## are effective antimicrobial agents (compounds of Formula II.), and potent anti-inflammatory agents of decreased acute toxicity (compounds of Formula I.).

2-Substituted-aminopropene-and propanenitrile antimicrobial and

Compounds of the structure: ##STR1## where A is either ##STR2## where R.sub.1 to R.sub.4 are various substituents are active as antibacterials and antifungals.

Anti-microbial piperidino buten-2-ones

Loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity. One particular compound, 1-amino-3-{{3-[4-(1-methylethyl)-phenyl]-1-{2-[4-(methylethyl)-phenyl]ethy l}propyl}amino}-2-propanol, and salts thereof is particularly useful as an udder wash and teat dip for mastitis prevention in lactating cows. Compositions for such use are disclosed.

Loweralkyl substituted diphenyl polyamine as an antimicrobial agent

A method of treating pain, fever, and inflammation and pharmaceutical compositions for use therein, wherein the active ingredient comprises a compound of the formula; ##STR1##

Treatment of pain, fever, and inflammation with compositions containing

Novel diphenyl and loweralkyl substituted diphenyl polyamines are useful antimicrobial agents, as well as algae inhibitors. They are especially useful because of their low toxicity, and as such are advantageously included as the active agent in surgical scrubs, antibacterial soaps, as preservatives in cosmetic preparations, and the like. They also can be used for topical treatment of dermatological conditions having a bacterial origin or implication such as Acne vulgaris.

Diaryl-aliphatic-amino-aliphatic-piperazines

A method of treating pain, fever, and inflammation and pharmaceutical compositions for use therein, wherein the active ingredient comprises a compound of the formula: ##STR1## wherein A and R.sub.1 represent various substituents.

Antimicrobial agents suitable for use in aqueous systems for their preservation against biodeterioration include substitutedpiperidinomethyl-propenenitriles and propanenitriles. The unsaturated compounds are prepared by reaction of a suitable piperidine with cyano acetic acid and formaldehyde: the propane derivatives therefrom by nucleophilic addition. sp

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Englewood, NJ, United States of America

Nathaniel Grier