Lumiphore, Inc.

University of California

Biophor Diagnostics, Inc.

Nathaniel G Butlin

Jide Xu

Darren Magda

Todd M Corneillie

David Tatum

Kenneth N Raymond

Claude F Meares

Paul Whetstone

Anthony D'Aleo

Carlito Bangeles Lebrilla

Sarah M Cheal

Susan Lee

Nicolas L Young

Charles A Martin

The invention relates to ligands and complexes of metal ions with the ligands useful in various applications, including therapeutic and diagnostic applications.

Macrocyclic ligands with pendant chelating moieties and complexes thereof

The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.

Macrocycles

Di-macrocycles

Functionalized linear ligands and complexes thereof

The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds comprise hydroxypyridinonyl moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability.

Macrocyclic HOPO chelators

A sample collection container adapted to be connected to, and disconnected from, a sample collection adapter and a sample collection container cap. The sample collection adapter has a downward sloping interior surface that provides a free-flowing path for samples provided by a subject to the sample collection container. The sample collection adapter may have a three-dimensional rim that is curved in two different non-parallel planes.

Fluid sample collection system

The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.

Multi-color time resolved fluorophores based on macrocyclic lanthanide complexes

The present invention provides compositions and methods for detecting, analyzing, and identifying biomolecules. More particularly, the invention provides Element Coded Affinity Tags comprising a metal chelate and a metal ion and methods of using the tags to detect, analyze, and identify biomolecules including polypeptides, nucleic acids, lipids, and polysaccharides.

Element-coded affinity tags

Growing community of inventors

Pacifica, CA, United States of America

Nathaniel G Butlin