Juno Therapeutics Gmbh

Nathaniel Chartrand

Jeff D Smith

Mark J Gilbert

He Li

Christopher Glen Ramsborg

Pascal Beauchesne

Ryan P Larson

Valerie Odegard

Clinton Weber

Kathryn Lindsay Pollock

Tom Kowski

Claire L Sutherland

Brian Christin

Nathan K Yee

Mary Mallaney

Andrew W Walker

Kedar Himanshu Dave

Michael Gerard Covington

Richard James Getto, Jr

James Boyd Whitmore

Travis Beckett

Samuel Charles Blackman

Nathaniel Lambert

Mel Davis-pickett

Nikolaus Sebastian Trede

Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the provided embodiments, including the numbers of cells or units of cells administered and/or the potency of administered cells, provide various advantages, such as lower risk of toxicity in subjects administered the T cell compositions.

Determining toxicity risk in CAR T-cell therapy

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Seattle, WA, United States of America

Nathaniel Chartrand