Lifecell Corporation

Other

Tdbt IP Inc.

Nathaniel Bachrach

Aaron M Barere

Evan J Friedman

Hui Xu

Melissa Richter Bowley

Israel James Jessop

Benjamin T Kibalo

Li Ting Huang

Timothy Roock

Wenquan Sun

Rick T Owens

Mark Hayzlett

Hua Wan

Sangwook Park

Daniel L Cohen

Ming F Pomerleau

Eric Stec

Mrinal Shah

Israel Jessop

Jerson Mezquita

Melissa Richter

Scott Douglas Cornez

Mark R Hayzlett

Rick Owens

Graft materials and devices for surgical breast procedures, as well as methods of making graft devices, are described.

Graft materials for surgical breast procedures

Methods for producing crosslinked tissue matrices, crosslinked tissue matrices produced by such methods, as well as tissue products comprising such tissue matrices are disclosed. The methods comprise (1) dehydrating a collagen-containing tissue matrix to form a dehydrated collagen-containing tissue matrix; and (2) irradiating the dehydrated collagen-containing tissue matrix such that at least a portion of the dehydrated collagen-containing tissue matrix is crosslinked.

Methods for stabilizing collagen-containing tissue products against enzymatic degradation

Tissue compositions and methods of preparation thereof are provided. The tissue compositions can be used to treat or regenerate muscle tissue. The compositions can be configured to provide increased strength compared to other muscle matrices.

Devices including muscle matrix and methods of production and use

Graft materials and devices for surgical breast procedures may include a sheet of biocompatible material and a plurality of fenestrations distributed across a portion of the sheet of biocompatible material. The sheet of biocompatible material can have a first axis and a second axis coincident with the sheet of biocompatible material. The sheet of biocompatible material can also have a first edge that intersects the second axis and a second edge that intersects the second axis. The first axis can be orthogonal to the second axis. The plurality of fenestrations can be distributed across a portion of the sheet of biocompatible material closer to the first edge than the second edge. Other apparatuses and methods are disclosed.

The present disclosure provides tissue products produced from extracellular tissue matrices. The tissue products can include acellular extracellular matrices including combinations of different tissue types. The combination can harness various properties of the different tissues to provide improved composite structures with desired mechanical and/or biologic properties.

Tissue matrices incorporating multiple tissue types

Disclosed herein are tissue-based drain manifolds comprising partially or completely decellularized tissue that has been processed to form tubes, columns, sheets, or other shapes and which are useful for managing the drainage of fluid and/or the administration of negative pressure at an implant site in a patient. The manifolds can be implanted in a patient and provide a natural scaffold in which native cells from surrounding tissue can migrate and proliferate, thereby avoiding the need to remove the implanted manifolds after drainage is complete.

Tissue-based drain manifolds

Elongated and high aspect ratio tissue treatment products are provided. Methods of making and using the tissue treatment products are also provided. The tissue treatment products can be used as implants that conform to the site of implantation and resist migration away from their implantation site in vivo.

Elongated tissue matrices

Tissue products lacking a desired percentage of immunogenic epitopes, such as galactose alpha-1,3 galactose epitopes, are provided. Methods of making and using the tissue products are also provided.

Methods of removing alpha-galactose

Graft materials and devices for surgical breast procedures, as well as methods of making graft devices are described.

Growing community of inventors

Clifton, NJ, United States of America

Nathaniel Bachrach