Massachusetts Institute of Technology

Flagship Pioneering Innovations V, Inc.

Dsm Nutritional Products Inc.

Nathan Wilson Stebbins

Geoffrey Von Maltzahn

Molly Krisann Gibson

Ram Sasisekharan

Karthik Viswanathan

Rahul Raman

Kannan Tharakaraman

Jacob Rosenblum Rubens

John Miles Milwid

Neal Gordon

Bo Zhang

Michael Travis Mee

Kiana Mahdaviani

Akila Jayaraman

Kyle Marvin Trudeau

Matthew Milnes Dobbin

Ruth Thieroff-ekerdt

Brigham Jay Hartley

Tamar Rose Putiri

Neal Francis Gordon

Geoffrey A Von Maltzahn

Ruth Thieroff-Ekerdt

Compositions, e.g., pharmaceutical compositions, nutritional compositions, medical foods, and food ingredients, as well as their methods of use, are provided, for treating diseases associated with hyperammonemia, e.g., urea cycle disorders (UCD) and hepatic encephalopathy (HE), e.g., minimal HE (MHE) and overt HE (OHE), and modulating enzyme activities and levels of microbes and taxa, and metabolites (e.g., ammonia) in the microbiome of a subject.

Glucose glycans for treating urea cycle disorders

In some aspects, fusosome compositions and methods are described herein that comprise membrane enclosed preparations, comprising a fusogen. In some embodiments, the fusosome can the target cell, thereby delivering complex biologic agents to the target cell cytoplasm.

Compositions for facilitating membrane fusion and uses thereof

The present invention provides, among other things, systems (e.g., comprising compositions and/or methods) for diagnosis, prophylaxis, treatment, prevention, and/or characterization of influenza transmission and/or infection. The present invention also provides methods for monitoring influenza variants for their potential to present a pandemic risk to humans.

Human Adaptation of H7 HA

Growing community of inventors

Cambridge, MA, United States of America

Nathan Wilson Stebbins