Carl Zeiss Meditec Gmbh

Carl Zeiss Meditec Ag

Nathan Shemonski

Alexandre R Tumlinson

Matthew J Everett

Tilman Schmoll

Yuan Liu

Homayoun Bagherinia

Mary K Durbin

Systems and methods for improved interferometric imaging are presented. One embodiment is a partial field frequency-domain interferometric imaging system in which a light beam is scanned in two directions across a sample and the light scattered from the object is collected using a spatially resolved detector. The light beam could illuminate a spot, a line or a two-dimensional area on the sample. Additional embodiments with applicability to partial field as well as other types of interferometric systems are also presented.

Frequency-domain interferometric based imaging systems and methods

Various methods for reducing artifacts in OCT images of an eye are described. In one exemplary method, three dimensional OCT image data of the eye is collected. Motion contrast information is calculated in the OCT image data. A first image and a second image are created from the motion contrast information. The first and the second images depict vasculature information regarding one or more upper portions and one or more deeper portions, respectively. The second image contains artifacts. Using an inverse calculation, a third image is determined that can be mixed with the first image to generate the second image. The third image depicts vasculature regarding the same one or more deeper portions as the second image but has reduced artifacts. A depth dependent correction method is also described that can be used in combination with the inverse problem based method to further reduce artifacts in OCT angiography images.

Systems and methods for reducing artifacts in oct angiography images

Various optical systems equipped with diode laser light sources are discussed in the present application. One example system includes a diode laser light source for providing a beam of radiation. The diode laser has a spectral output bandwidth when driven under equilibrium conditions. The system further includes a driver circuit to apply a pulse of drive current to the diode laser. The pulse causes a variation in the output wavelength of the diode laser during the pulse such that the spectral output bandwidth is at least two times larger than the spectral output bandwidth under the equilibrium conditions.

Interferometry with pulse broadened diode laser

Various optical systems equipped with diode laser light sources are discussed in the present application. One example system includes a diode laser light source for providing a beam of radiation. The diode laser has a spectral output bandwidth when driven under equilibrium conditions. The system further includes a driver circuit to apply a pulse of drive current to the diode laser. The pulse causes a variation in the output wavelength of the diode laser during the pulse such that the spectral output bandwidth is at least two times larger the spectral output bandwidth under the equilibrium conditions.

An ophthalmic image diagnostic tool and method submits a test image to a neural network trained to identify abnormal regions of an ophthalmic image, to distinguish between multiple types of abnormalities, and to associate an abnormality type with each identified potentially abnormal region. Each potentially abnormal region in the test image is highlighted, and in response to a user-selection of a highlighted region, a previously diagnosed sample (e.g., from a library of samples) of the abnormality type associated with the selected highlighted region is displayed.

Identifying suspicious areas in ophthalmic data

Systems and methods for reducing artifacts in OCT angiography images

Various systems and methods for sequential angle illumination to achieve ultra-high resolution optical coherence tomography (OCT) images. One example OCT system includes a light source, a beam divider, sample arm optics, a detector, and a processor. The light source generates a light beam to illuminate the sample. The beam divider separates the light beam into reference and sample arms. The sample arm optics sequentially illuminates a location in the sample with the light beam from different angles. The detector receives light returned from the reference arm and the sample illuminated at each angle and generates signals. The processor combines the signals to generate an image, which has a transverse resolution that is higher than the transverse resolution achieved from the signal generated from a single angle.

Systems and methods for improved OCT measurements

An efficient OCT data collection and processing method for obtaining a high-axial-resolution image with explicit ranging over an extended depth is described. The method includes collecting a first dataset at a transverse location of the sample. The first dataset comprises spectra of a bandwidth (&#x394;k) sampled at a spectral sampling interval (dk). A second dataset comprising spectra of a bandwidth (&#x394;k) sampled at a spectral sampling interval (dk) is collected. The bandwidth &#x394;kis less than &#x394;kand spectral sampling interval dkis less than dk. The first and the second datasets are processed to generate at least one A-scan with an axial resolution higher than the axial resolution corresponding to the bandwidth &#x394;kand a depth range larger than the depth range provided by sampling interval dk.

Efficient sampling of optical coherence tomography data for explicit ranging over extended depth

Various balanced detection systems which reduce alignment requirements of free space optics based balanced detection configurations are discussed. One example system includes a light source, a beam divider, sample optics, return optics, and a processor. The light source generates a light beam. The beam divider separates the light beam into reference and sample arms. The sample optics deliver the light beam in the sample arm to a light scattering object to be imaged. The return optics direct light to a balanced detection system, which has a balanced detection beam divider for combining light scattered from the object and light from the reference arm and directing the combined light into two detection channels and two detectors for collecting the combined light in the two detection channels and generating signals in response thereto. The processor processes the signals and generates image data of the object based on the processed signals.

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San Francisco, CA, United States of America

Nathan Shemonski