Massachusetts Institute of Technology

The Governors of the University of Alberta

Harvard College

Nathan Klapoetke

Edward Stuart Boyden

Brian Yichiun Chow

Yongku Peter Cho

Gane Ka-Shu Wong

Amy S Chuong

Xue Han

Fei Chen

Adam Ezra Cohen

Daniel Hochbaum

Gane K S Wong

The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.

Channelrhodopsins for optical control of cells

CsChrimson light-activated ion channel polypeptides, their encoding polynucleotides, and variants thereof are provided. Methods of introducing and using CsChrimson light activated ion channels and variants thereof for to alter cell activity and function are also provided.

Channelrhodopsin variants and uses thereof

The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of mutant light-activated ion channels and variants thereof.

Mutant channelrhodopsins with altered ion selectivity

The invention, in some aspects relates to light-activated ion channel polypeptides and encoding nucleic acids and also relates in part to compositions comprising light-activated ion channel polypeptides and methods using light-activated ion channel polypeptides to alter cell activity and function.

Blue-light-activated ion channel polypeptides and uses thereof

Compositions and methods for altering cell activity and function by expressing a light-activated ion pump polypeptide in a cell and contacting the cell with light that activates the expressed light-activated ion pump polypeptide. In some aspects of the invention, a light-activated ion pump polypeptide is a modifiedhalorhodopsin polypeptide, for example, a modified Halo 57 polypeptide.

Red-shifted opsin molecules and uses thereof

The invention, in some aspects, relates to compositions and methods for altering cell activity and function. The invention also relates, in part, to the use of light-activated ion pumps (LAIPs) such as a light-activated ion pump polypeptide that when expressed in an excitable cell and contacted with a red light silences the excitable cell, wherein the polypeptide sequence of the light-activated ion pump comprises a wild-type or modifiedorhalorhodopsin polypeptide sequence.

Growing community of inventors

Ashburn, VA, United States of America

Nathan Klapoetke