Mayo Foundation for Medical Education and Research

Nathan K LeBrasseur

Tamar Tchkonia

James L Kirkland

Yi Zhu

Jordan D Miller

Allyson K Palmer

Provided herein are methods and uses for treatment or prophylaxis of a senescent cell associated disease or disorder by administering a senolytic combination comprising dasatinib and quercetin or an analog thereof to a subject in need thereof. In certain embodiments, the senescent cell associated disease or disorder is a cardiovascular disease or disorder, inflanunatory disease or disorder, a pulmonary disease or disorder, a neurological disease or disorder, or a metabolic disease or disorder.

Growing community of inventors

Rochester, MN, United States of America

Nathan K LeBrasseur