Merck + Co., Inc.

Other

Nathan G Steinberg

Gary H Rasmusson

Thomas N Salzmann

Burton G Christensen

Richard L Tolman

William K Hagmann

Philippe L Durette

Bruce E Witzel

Donald W Graham

Soumya P Sahoo

Ihor E Kopka

Alan D Adams

Craig K Esser

F Aileen Bouffard

A clip that can be either permanently affixed to a tube or removable from a tube having foldable wings is folded about the tube allowing the user to fully extrude the product contained within the tube. In order to retain the folded shape of the tube, the clip has foldable wings, which are folded around the tube.

Clip for squeezing tubes

Described are new 16-substituted and 7,16-disubstituted 4-aza-5.alpha.-androstan-3-ones and related compounds as 5.alpha.-reductase inhibitors.

Substituted 4-aza-5.alpha.-androstan-ones as 5.alpha.-reductase

Compounds of the formula ##STR1## are inhibitors of 5.alpha.-reductase and are useful alone or in combination with other active agents for the treatment of hyperandrogenic disorders such as acne vulgaris, seborrhea, female hirsutism, male pattern baldness, and benign prostatic hyperplasia.

17b-aryl-4-aza-steroid derivatives useful as 5-alpha-reductase inhibitors

Selected 17.beta.-Polyaroyl-4-aza-5.alpha.-androst-1-en-3-ones as steroidal reductase inhibitors of the formula: ##STR1## wherein R is selected from hydrogen, methyl and ethyl

Selected 17 .beta.-polyaroyl-4-aza-5 .alpha.-androst-1-en-3-ones as

Specific 17.beta.-thiobenzoyl-4-aza-5.alpha.-androst-1-en-3-ones as antiandrogenic agents of the formula: ##STR1## wherein R is selected from hydrogen, methyl and ethyl and

Specific 17.beta.-thiobenzoyl-4-aza-5.alpha.-androst-1-en-3-ones as

Novel 17.beta.-hydroxybenzoyl-4-aza-5.alpha.-androst-1-en-3-ones as tetosterone reductase inhibitors of the formula: ##STR1## wherein R is selected from hydrogen, methyl and ethy and

17.beta.-hydroxybenzoyl-4-aza-5.alpha.-androst-1-en-3-ones as

New 17.beta.-aminobenzoyl-4-aza-5.alpha.-androst-1-en-3-ones as benign prostatic hypertrophy agents of the formula: ##STR1## wherein R is selected from hydrogen, methyl and ethyl and

17.beta.-aminobenzoyl-4-aza-5.alpha.-androst-1-en-3-ones as benign

Disclosed are Schiff's base derivatives of the antibiotic thienamycin, which has the following structure: ##STR1## Such compounds and their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such derivatives, pharmaceutical compositions comprising such derivatives, and methods of treatment comprising administering such derivatives and compositions when an antibiotic effect is indicated.

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Clark, NJ, United States of America

Nathan G Steinberg