Sri International

Nathan Collins

Peter Madrid

Jeremiah Malerich

Kathlynn C Brown

Michael McGuire

Curtis Allred

Pauline Bourbon

Keen Chung

Shunzi “Susan” Li

Michal Avital-Shmilovici

Wan-Ru Chao

Brian Keith McCoy

Kevin Luebke

Jason D White

Lidia Sambucetti

Markus Krummenacker

Dominic Dinh

Mario Latendresse

Judy Szeto

Kristina Rucker

Joseph A Kozocas

Thomas Shaler

Brian K Mccoy

Disclosed are compositions comprising an antibody conjugated to one or more molecular guidance system (MGS) peptides. Disclosed are methods of treating a subject in need thereof comprising administering to the subject in need thereof an effective amount of an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target involved in the disease process. Disclosed are methods of targeting an intracellular target comprising administering an antibody conjugated to one or more MGS peptides, wherein the antibody targets an intracellular target.

Molecular guide system peptides and uses thereof

Embodiments in accordance with the present disclosure are directed to polymer beads and uses thereof, including forming libraries of compounds for screening and assay purposes. An example method includes using logic circuitry to: select a plurality of molecules that include a plurality of subgroups, each of the plurality of molecules exhibiting a mass spectrometry characteristic that is distinguishable from mass spectrometry characteristics of other molecules of the plurality, and assign the plurality of molecules with a position in a sequence of a plurality of synthetic compounds forming a library. The method further includes defining, as data in a memory circuit of the logic circuitry, the plurality of synthetic compounds that are sequenceable via mass spectrometry using the assigned positions of the plurality of molecules for communicating to other circuitry for formation thereof via coupling chemistry or screening of a particular function.

Mass spectrometry distinguishable synthetic compounds, libraries, and methods thereof

Retrosynthetic methods are described for determining one or more optimal synthetic routes to generate a target compound.

Computational generation of chemical synthesis routes and methods

Embodiments in accordance with the present disclosure are directed to apparatuses used for reaction screening and optimization purposes. An example apparatus includes a plurality of reaction vessels, a dispensing subsystem, at least one reactor module, an analysis subsystem, an automation subsystem, and control circuitry. The dispensing subsystem delivers reagents to the plurality of reaction vessels for a plurality of reaction mixtures having varied reaction conditions. The at least one reactor module drives a plurality of reactions within the plurality of reaction vessels. The analysis subsystem analyzes compositions contained in the plurality of reaction vessels. The automation subsystem selectively moves the plurality of reaction vessels from a location proximal to the dispensing subsystem to the at least one reactor module based on experimental design parameters. And, the control circuitry identifies optimum reaction conditions for a target end product based on the analysis.

Apparatuses for reaction screening and optimization, and methods thereof

This disclosure generally relates to methods of making ibuprofen, naproxen, and derivatives thereof. This disclosure also generally relates to compounds made by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Continuous flow synthesis of ibuprofen

Embodiments in accordance with the present disclosure are directed to polymer beads and uses thereof, including forming libraries of compounds for screening and assay purposes. A polymer bead, in accordance with embodiments, has an interior surface and an exterior surface that are topologically segregated from one another. The interior surface includes a protecting group and the exterior surface includes a deprotected group, which can also be referred to as a deprotected functional group. The protecting group can includes a nitrobenzenesulfonamide group that protects an amine group.

Topologically segregated polymer beads and methods thereof

The disclosure provides compositions and methods for treating multiple myeloma. In some embodiments, the compositions comprise (E)-3-hydroxy-21-[2'-(N,N-dimethylamino)ethoxy]-19-norpregna-1,3,5(10),17(20)-tetraene or a pharmaceutically acceptable salt or prodrug thereof and a pharmaceutical carrier.

Compositions and method for the treatment of multiple myeloma

Growing community of inventors

San Mateo, CA, United States of America

Nathan Collins