University of California

Northwestern University

The University of Akron

Vybyl Holdings, Inc.

Elevance Renewable Sciences, Inc.

Nathan C Gianneschi

Paul A Bertin

Matthew P Thompson

Cassandra E Callmann

Clare L M LeGuyader

Anthony M Rush

Ali Dhinojwala

Ming Xiao

Angela P Blum

Carrie James

Jacquelin K Kammeyer

Yuran Huang

Yiwen Li

Chad A Mirkin

Karen L Christman

Jungseok Heo

Andrea S Carlini

Zofia Elzbieta Siwicka

Wei Cao

Ziying Hu

Matthew Shawkey

Erick T Tatro

Miao-Ping Chien

In an aspect, an artificial selenomelanin material comprises: one or more selenomelanin polymers; wherein the one or more selenomelanin polymers comprise a plurality of covalently bonded selenomelanin base units; and wherein a chemical formula of each of the one or more selenomelanin base units comprises at least one selenium atom. Optionally, each selenomelanin polymer is a pheomelanin. Preferably, the chemical formula of each of the one or more selenomelanin base units comprises at least one covalent bond with each of the at least one selenium atom.

Selenium-containing analogues of pheomelanin and related materials and methods of making

Included herein are methods and materials for nontoxic, biocompatible, optionally metal-free, tunable, and long-lasting coloration of human hair. More particularly, provided herein are methods, and associated formulations, for efficient formation and deposition of synthetic melanin to human hair, thereby coloration of hair, whereby the hair treatment formulation is viscous enough for treatment of hair without substantially loss of the formulation which further allows an easier application process that includes exposing the hair to the treatment formulation for an extended amount of time. For example, the hair treatment formulation, or viscous solution, can be applied and left on the hair, such as if it were a cream or gel, without requiring soaking the hair in a bath. Different colors can be achieved by tuning reaction conditions such as temperature and solution phase composition. These methods, and associated materials, can be used in salons and at home, for example, without degradation of the resulting colored hair and safety of the user of the present materials and methods.

Melanin hair dye with thickeners

In various embodiments, the present invention is directed to a facile one-pot reverse emulsion process to assemble core-shell nanoparticles (CS-SMNPs) into bright and noniridescent photonic supraballs. In one or more embodiments, the present invention is directed to core-shell nanoparticles having an inner high refractive index (RI) core and an outer low RI shell. In one or more embodiment, the present invention includes core-shell nanoparticles using high RI (˜1.74) melanin cores and low-RI (˜1.45) silica shells. In various embodiments, these nanoparticles may be self-assembled into bright and noniridescent supraballs using a scalable one-pot reverse emulsion process. According to various embodiments of the present invention, it is possible to generate a full spectrum of structural colors with the combination of only two ingredients, synthetic melanin and silica.

Self-assembled melanin particles for color production

Provided herein are compositions and methods of making high density nucleic acid polymers.

Compositions and methods of making polymerized nucleic acids

Provided, inter alia, are synthetic melanin nanoparticles (MelNPs) useful for protecting keratinocytes from UV-damage and for treating melanin-defective diseases.

Synthetic melanin nanoparticles and uses thereof

In various embodiments, the present invention is directed to a supraparticle for use in producing structural colors comprising a plurality of core/shell nanoparticles having a melanin or synthetic melanin core and a silica shell having a plurality of silanol groups on its outer surface and a poly(ethylene glycol) (PEG) crosslinker. In various embodiments, the structure of these crosslinked supra particles is reinforced by hydrogen bonds formed between the silanol groups on the core-shell nanoparticles and mechanical, solution phase, and dry state stability.

Stabilization of melanin-based supraparticles using polymeric glue

Described herein, inter alia, are peptide containing polymers, and methods of making and using the same.

High density peptide polymers

Cyclic peptide pro-gelator compositions, and methods of therapeutic use, which assemble into macromolecular hydrogel when administered through cleavage by endogenous enzymes upregulated at a site of tissue injury, such as a myocardial infarction.

Catheter injectable cyclic peptide pro-gelators for myocardial tissue engineering

Compositions and methods of making polymerizing nucleic acids

The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are chemically modified to include one or more moieties that include hydrophobic portions. In some embodiments, the disclosure provides small-molecule cytotoxins that are chemically modified with fatty acid-containing moieties. In some aspects, the disclosure provides compositions, such as pharmaceutical compositions, that include such modified small-molecule cytotoxins and a protein. In some embodiments, the protein is albumin or an albumin mimetic. Further, the disclosure provides various uses of these compounds and compositions.

Modified cytotoxins and their therapeutic use

There are disclosed compositions and methods to render nucleic acids resistant to nuclease digestion while maintaining sequence selective hybridization competency. The approach relies on utilizing nucleic acids as the polar head group of a nucleic acid-polymer amphiphile in order to assemble well-defined, discrete micellar nanoparticles. Dense packing of nucleic acid in the micelle corona allows for hybridization of complementary oligonucleotides while prohibiting enzymatic degradation.

Growing community of inventors

La Jolla, CA, United States of America

Nathan C Gianneschi