Medivir Ab

Nathalie Roue

Christer Sahlberg

Christian Sund

Dmitry Antonov

Stefan Lindstrom

Katarina Jansson

Compounds of the formula Z: where; A is CH or N; Ris a substituent to a carbon atom in the ring containing A selected from &#x2014;S(&#x2550;O)Ra, where Ra is &#x2014;C-Calkyl, &#x2014;ORx, &#x2014;NRxRx, &#x2014;NHNRxRx, &#x2014;NHNHC(&#x2550;O)ORx, &#x2014;NRxOH; &#x2014;C(&#x2550;O)&#x2014;Rb, where Rb is &#x2014;CT-C4-alkyl, ORx, &#x2014;NRxRx, &#x2014;NHNRxRx, &#x2014;NHC-C-alkyl-C(&#x2550;O)Orx &#x2014;NRxRc, where Rc is H, C-Calkyl, &#x2014;NRxRx; &#x2014;C(=0)Rd, &#x2014;CN, S(&#x2550;O)pRx, where Rd is Rd is C1-C4-alkyl, &#x2014;ORx, &#x2014;NRxRx C-C-alkyl-O&#x2014;C1-C3-alkylC(&#x2550;O)ORx, &#x2014;C-C-alkyl-COORx; &#x2014;C-Calkyl-OH or C-Calkyl ethers or esters thereof (O&#x2014;C-Calkyl)q-O&#x2014;Rx a 5 or 6 membered aromatic ring having 1-3 hetero atoms p is 1 or 2; Rx is independently selected from H, C-Calkyl or acetyl; or a pair of Rx can together with the adjacent N atom form a ring; L is -0-, &#x2014;S(&#x2550;O)&#x2014;, or &#x2014;CH&#x2014;, where r is 0, 1 or 2; R-Rare substituents as defined in the specification; X is &#x2014;(CRR')n-D-(CRR&#x2032;)m-; D is a bond, &#x2014;NR&#x2014;, -0-, &#x2014;S&#x2014;, &#x2014;S(=0)- or &#x2014;S(=0)-; and pharmaceutically acceptable salts and prodrugs thereof, have utility as HIV antivirals. 

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Huddinge, Sweden

Nathalie Roue