Centre National De La Recherche Scientifique

Institut Pasteur De Lille

Université De Lille

Universitá Degli Studi Di Pavia

Université Lille 2 - Droit Et Santé

Université De Lille 1 - Sciences Et Technologies

Université De Lille 2 Droit Et Santé

Nathalie Ollivier

Oleg Melnyk

Julien Dheur

Reda Mhidia

Laurent Raibaut

Ermanno Gherardi

Berenice Leclercq

Hugo De Jonge

Claire Simonneau

Jerome Vicogne

Giovanni De Nola

Eric Adriaenssens

Disclosed are proteins derived from the HGF/SF which are able to induce activation of the tyrosine kinase receptor MET and their uses, in particular to promote tissue regeneration. Further disclosed are nucleic acid molecules coding such protein, expression vectors containing such nucleic acid molecule, host cells containing such expression vectors, and related compositions.

MET receptor agonist proteins

Method for preparing a peptide assembly of n fragments and n&#x2212;1 amino acids bearing a thiol function, represented by the formula:A-C-A-C-A- . . . -C-A- . . . -C-A&#x2003;&#x2003;(I)in which A, A, A, . . . A. . . , Aare peptide fragments, C, C, C. . . C. . . Care amino acid residues bearing a thiol function, n is comprised between 3 and 50, and i is 2 to n, in which a peptide-thioester is prepared of formula: A-SR (II) in which Ais a peptide fragment and SR is an alkyl thioester residue, R being alkyl optionally substituted, starting from a bis(2-sulphanylethyl)amino peptide.

Method for preparing peptides by assembling multiple peptide fragments

A method for producing a polypeptide, includes at least one native ligation step using a peptide functionalized with a selenium group. The selenium peptides and compounds are also described.

Native ligation process

The invention mainly relates to a method for manufacturing a polypeptide of formula:X&#x2014;X&#x2033;&#x2014;X&#x2003;&#x2003;(III)Xand Xeach representing a peptide fragment, and X&#x2033; representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypeptide of formula:X&#x2014;N(CHCHSH)&#x2003;&#x2003;(I)and a polypeptide of formula:H&#x2014;X&#x2033;&#x2014;X.&#x2003;&#x2003;(II) The invention also relates to the polypeptides of formula (I) themselves and the method for obtaining them, as well as resin supports suitable for obtaining them.

Method for native ligation of polypeptides

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Roubaix, France

Nathalie Ollivier