Centre National De La Recherche Scientifique

Assistance Publique-hopitaux De Paris

Ecole Nationale Superieure De Chimie De Paris

Institut National De La Sante Et De La Recherche Medicale

Université De Paris

Institut National De La Recherche Scientifique

Universite Paris Cité

Universite De Versailles-st Quentin En Yvelines

Gencell, S.a.

Sorbonne Université

Universite Claude Bernard – Lyon1

Institut National De La Sante Et De La Recherche Medicale (inserm)

Université De Paris 5 René Descartes

Ecole Nationale Superieure De Chimie Paris

Nathalie Mignet

Daniel Scherman

Olivier Tillement

François Lux

Johanne Seguin

Vincent Boudy

Kathia Lemdani

Michel Bessodes

Jean Herscovici

Pascal Houze

Vincent Pierre-Marie Boudy

Yoran Beldengrun

Rabah Gahoual

Hugo Salmon

Isabelle Tranchant

Christian Girard

Robert Malafosse

Claude Capron

Grégory Ramniceanu

Bich-Thuy Doan

Yohann Corvis

Brice Martin

Yongmin Zhang

Lucie Sancey Galliot

The present invention relates to an asymmetric flow field-flow fractionation device () configured to separate a sample () of particles () dispersed in a liquid mobile phase (), the device including a fractionation microchannel () comprising a sample inlet, a sample outlet, an auxiliary microchannel () comprising an auxiliary outlet, a semipermeable membrane () separating the fractionation microchannel () and the auxiliary microchannel (), said membrane being permeable to liquid and being configured to maintain the particles () in said fractionation microchannel (), the fractionation microchannel () being superimposed on the auxiliary microchannel (), wherein the device () comprises two layers (), each layer being with a microfabricated recess () which thickness (t) is less than 100m, the membrane () being mechanically held in between the two layers (), the recesses () respectively defining the fractionation microchannel () and the auxiliary microchannel () on each side of the membrane ().

Microfluidic asymmetric flow field-flow fractionation device and method of using the same

The present invention concerns a thermosensitive polymeric hydrogel comprising at least one thermosensitive copolymer, one aqueous solution, and a mucoadhesive excipient, wherein said thermosensitive polymeric hydrogel further comprises at least one immunostimulatory adjuvant and/or at least one cytokine and/or at least one chemokine and/or atleast one heat shockprotein. Another object of the invention is a thermosensitive polymeric hydrogel according to the invention for use in the treatment of tumors or metastasis in a subject having a cancer, preferably a metastatic cancer.

Immunomodulation after locoregional anti-tumoral treatment

The present invention relates to gelling compositions, which changes from liquid state to gel state in function of temperature comprising: at least a poloxamer or mixture of poloxamers; at least a gelling agent; and at least an anticancer agent. Said compositions are advantageously used for local administration of an anticancer agent. Said compositions are useful for size-reduction of a tumour before surgical removal of said tumour, for preventing tumour recurrence after surgical removal of a tumour, and/or treating small tumours. They are therefore useful for the treatment of cancer, preferably a cancer of a wall of the digestive system or a gynaecologic cancer. The present invention also relates to a method for preparing said gelling compositions.

Gelling compositions for treating malignant tumours and/or preventing tumour recurrence

The present invention relates to novel compounds which make it possible to transfer nucleic acids into cells. These novel compounds are lipid derivatives of polythiourea. They are useful for the in vitro, ex vivo or in vivo transfection of nucleic acids into various cell types.

Lipid derivatives of polythiourea

Growing community of inventors

Clamart, France

Nathalie Mignet