Smithkline Beecham Biologicals S.a.

Glaxosmithkline Biologicals Sa

Nathalie Garcon

Jean Stephenne

Martin Friede

Moncef Mohamed Slaoui

Catherine Marie Ghislaine Gerard

Philippe Hermand

Christian Van Hoecke

Patricia Marie Christine Aline Francoise Momin

The present provide vaccine and adjuvant formulation comprising an immunostimulant and a metal salt. The immunostimulant is adsorbed on to a particle of metal salt and the resulting particle is essentially devoid of antigen.

Vaccine

The invention relates to methods for one-dose influenza vaccine for intradermal delivery of a trivalent, non-live influenza antigen preparation, particularly a split influenza preparation.

Methods for one-dose intradermal delivery for non-live trivalent influenza vaccine

An adjuvant composition comprising monophosphoryl lipid A or a derivative of monophposphoryl lipid A adsorbed onto an aluminium salt particle.

Adjuvant systems and vaccines

The invention relates to the use of a trivalent, non-live influenza antigen preparation, particularly a split influenza preparation, in the manufacture of a one-dose influenza vaccine for intradermal delivery. In particular, the invention relates to the use of split influenza preparations wherein the vaccine comprises at least one non-ionic surfactant selected from the group consisting of the octyl-or nonylphenoxy polyoxyethanols (for example the commercially available Triton&#x2122; series), polyoxyethylene sorbitan esters (Tween&#x2122; series) and polyoxyethylene ethers or esters of general formula (I): HO(CHCHO)-A-R, wherein n is 1-50, A is a bond or &#x2014;C(O)&#x2014;, R is Calkyl or phenyl Calkyl; and combinations of two or more of these.

Non-live trivalent influenza vaccine for one-dose intradermal delivery

The present invention relates to adjuvant compositions which are suitable to be used in vaccines. In particular, the adjuvant compositions of the present invention comprises a saponin and an immunostimulatory oligonucleotide, optionally with a carrier. Also provided by the present invention are vaccines comprising the adjuvants of the present invention and an antigen. Further provided are methods of manufacture of the adjuvants and vaccines of the present invention and their use as medicaments. Methods of treating an individual susceptible to or suffering from a disease by the administration of the vaccines of the present invention are also provided.

Vaccines

The present invention provides vaccine and adjuvant formulation comprising an immunostimulant and a metal salt. The immunostimulant is adsorbed onto a particle of metal salt and the resulting particle is essentially devoid of antigen.

The present invention relates to an oil in water emulsion vaccine composition. In particular, the present invention relates to a vaccine adjuvant formulation based on oil in water emulsion comprising a metabolisable oil and a saponin, wherein the oil and a saponin are present in a ratio of between 1:1 and 200:1. The invention further relates to methods for preparing the emulsion and its use in medicine.

Oil in water emulsions containing saponins

The present invention provides an improved adjuvant formulation and a process for producing said adjuvant. The adjuvant comprises an ISCOM structure comprising a saponin, said ISCOM structure being devoid of additional detergent.

Vaccine comprising an iscom consisting of sterol and saponin which is free of additional detergent

The present invention relates to oil in water emulsion compositions, their use in medicine, in particular to their use in augmenting immune responses to a wide range of antigens, and to methods of their manufacture; the compositions having oil phase and an aqueous phase, a sterol and a saponin; the sterol being present in the oil phase and the saponin being present in the aqueous phase.

Growing community of inventors

Rixensart, Belgium

Nathalie Garcon