Sanofi

Sanofi-aventis

Mitsubishi Tanabe Pharma Corporation

Mitsubishi Pharma Corporation

Nathalie Chereze

Mourad Saady

Philippe Yaiche

Alistair Lochead

Ahmed Abouabdellah

Julien Vache

Franck Slowinski

Aude Fayol

Corinne Veronique

Thierry Gallet

The invention relates to a compound of the general formula (I) in which Ris a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C-alkyl, C-alkoxy, NRRgroup; m, n, o and p are independently an integer equal to 0, 1, 2 or 3; A is a covalent bond or a C-alkylene group; Ris an optionally substituted aryl or heteroaryl group; Ris a hydrogen or fluorine atom or a C-alkyl group or a trifluoromethyl group; Ris an optionally substituted 5-member heterocyclic compound; the compound being in the form of a base or acid addition salt. The invention also relates to the therapeutic use thereof. 

Derivatives of azaspiranyl-alkylcarbamates of 5-member heterocyclic compounds, preparation thereof and therapeutic use thereof

Compound corresponding to general formula (I): in which Ris a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C-alkyl, C-alkoxy or NRRgroup; n is an integer equal to 1, 2 or 3 and m is an integer equal to 1 or 2; A is a covalent bond or a C-alkylene group; Ris a phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, naphthyl, quinolinyl, isoquinolinyl, phthalazinyl, quinazolinyl, quinoxalinyl, cinnolinyl or naphthyridinyl group, this group being optionally substituted; Ris a hydrogen or fluorine atom, a C-alkyl group or a tritluoromethyl group; Ris a group selected from furanyl, pyrrolyl, thienyl, isothiazolyl, oxazolyl, isoxazolyl, pyrazolyl, oxadiazolyl, thiadiazolyl, imidazole, triazolyl, tetrazolyl, oxazolone, oxazolidinone, isoxazolone, isoxazolidinone, isothiazolone, isothiazolidinone, imidazolone, imidazolidinone, pyrazolone, pyrazolidinone, oxadiazolone, thiadiazolone and triazolone, this group being optionally substituted; in the form of a base or of an addition salt with an acid. Therapeutic use. 

Carbamate derivatives of alkyl-heterocycles, preparation thereof and therapeutic use thereof

The present invention discloses a series of pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: Wherein X, Z, R1, R2, R3, R4, R5, R6, R7, n and m are as defined herein. Also disclosed herein are the methods of preparation of compounds of formula (I), intermediates therefor and their utility in treating a variety of disease conditions.

Heteroarylamide pyrimidone derivatives

Arylamide pyrimidone derivatives

The invention relates to compounds of the general formula (I) where: Ris a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C-alkyl, C-alkoxy, or NRRgroup; m, n, o and p independently are a number from 0 to 3, provided that m+n&#x2266;7 and that o+p&#x2266;7; A is a covalent bond, an oxygen atom, a C-alkylene group or a &#x2014;O&#x2014;C-alkylene group in which the end that is an oxygen atom is bonded to the Rgroup and the end that is an alkylene group is bonded to the carbon of the bicyclic compound; Ris an optionally substituted aryl or heteroaryl group; Ris a hydrogen or fluorine atom or a C-alkyl or trifluoromethyl group; Ris an optionally substituted 5-membered heterocyclic compounds; wherein the compounds can be in the state of a base or an acid addition salt. The invention can be used in therapeutics. 

7-aza-spiro[3.5]nonane-7-carboxylate derivatives, preparation thereof and therapeutic use thereof

A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: Wherein Y, Z, R1, R2, R3, R4, R5, R6, R7, n, m, and o are as described herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3&#x3b2;, such as Alzheimer disease.

Substituted bicyclic pyrimidone derivatives

The invention relates to a dihydrospiro-[cycloalkylamine]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein: X, Y, R1, R2, R3, R4, o, m, n, p and q are as defined herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3&#x3b2;, such as Alzheimer disease.

[object Object]

The invention relates to a dihydrospiro-[cycloalkylamine]-pyrimidone derivative represented by formula (I) or a salt thereof:  wherein X, Y, R1, R2, R3, R4, o, m, n, p and q are as defined herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3&#x3b2;, such as Alzheimer disease.

Growing community of inventors

Paris, France

Nathalie Chereze