Vertex Pharmaceuticals, Inc.

Nathalie Chauret

Laval Chan Chun Kong

Christophe Moinet

Marc Courchesne

Liliane Halab

Carl Poisson

Oswy Z Pereira

Bingcan Liu

Monica Bubenik

Caroline Cadilhac

Paul Nguyen-Ba

Nathalie Turcotte

The invention relates to 21-keto triterpene compounds of formula (I): wherein R, X and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.

C-21-keto lupane derivatives preparation and use thereof

The invention relates to 21-keto triterpene compounds of formula (I): wherein R, X, and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment. 

Lupane derivatives useful for treating HIV

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Ile Bizard, Canada

Nathalie Chauret