Novartis Ag

Novartis Animal Health Us, Inc.

Nathalie C Simard

Steven Gareth Griffiths

Rachael Jane Ritchie

Luis O Burzio

Pablo Valenzuela

Huub Brouwers

Simon Jones

Steve Griffiths

Linda Bootland

Linda M Bootland

The present invention relates to a fish vaccine. More specifically the invention relates to a vaccine to protect salmon against infection by. The invention is based on or derived from the nucleic acid or amino acid sequence of antigens from. Nucleic acid and/or amino acid sequences may be used in the preparation of a vaccine to protect against infection by

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The hsp60 gene from a strain ofhas been isolated and sequenced. The encoded protein is believed to be highly immunogenic, especially in fish, and also has utility as a non-specific adjuvant, and as an adjuvanting carrier for heterologous antigens.

HSP60 from arthrobacter

The hsp70 gene from anspecies has been isolated and sequenced. The encoded protein is believed to be highly immunogenic, especially in fish, and also has utility as a non-specific adjuvant, and as an adjuvanting carrier for heterologous antigens.

A vaccine comprises a portion of IHNV G protein and a portion of a second protein from a fish pathogen, or their respective nucleic acid coding sequences. The presence of the IHNV G protein boosts the immune response to the second protein, resulting in a protective effect against infection by the fish pathogen and/or mortality caused by the fish pathogen from which the second protein is derived.

IHNV G protein for immune stimulation

Hsp60 from arthrobacter

Sequences from Piscirickettsia salmonis

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Nathalie C Simard