Deutsches Krebsforschungszentrum

Ruprecht-Karls-Universitaet Heidelberg

Ruprecht-Karls-Universitat Heidelberg

Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts

Universitaetsklinikum Heidelberg

Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts

Universitatsklinikum Heidelberg

Nathalia Giese

Jean Rommelaere

Zahari Raykov

Marc Aprahamian

Laurent Daeffler

Svitlana Grekova

Thomas Giese

Celina Czeipluch

Jens Werner

Markus Buechler

Laurent DÄFFLER

Celina Cziepluch

Markus Büchler

Markus Buchler

Laurent Daffler

A parvovirus characterized by a CpG-enriched genome, wherein the genome contains at least 2 additional CpG inserts that are not present in the wild type genome is described as well as the use of said parvovirus, e.g., a parvovirus based on parvovirus H1, LuIII, Mouse minute virus (MMV), Mouse parvovirus (MPV), Rat minute virus (RMV), Rat parvovirus (RPV), Rat virus (RV), vectors based on the foregoing viral species, and/or cells capable of actively producing the foregoing viral species for the preparation of a pharmaceutical composition, e.g., for the treatment of cancer, preferably pancreas carcinoma, hepatoma or lymphoma.

Parovirus having a CpG-enriched genome useful for cancer therapy

The present invention relates to a combination of a parvovirus and a cytokine, preferably IFN, for use in treating pancreatic cancer, in particular a terminal stage of this disease.

Co-administration of a parvovirus and a cytokine for therapy of pancreatic cancer

Described is a diagnostic method for predicting the response of a patient to chemovirotherapy or radiovirotherapy, comprising exposing primary tumor cells from a patient, e.g., tumor cells obtained from a brain tumor or pancreatic cancer, to (i) a parvovirus and/or (ii) a chemotherapeutic agent or radiotherapy, and determining the reduction of the expression or concentration of ISG15.

Methods of treating cancer using chemovirotherapy

Parvovirus having a CPG-enriched genome useful for cancer therapy

Growing community of inventors

Schriesheim, Germany

Nathalia Giese