Regeneron Pharmaceuticals, Inc.

Natasha Levenkova

Andrew J Murphy

Lynn Macdonald

Naxin Tu

Vera Voronina

Faith Harris

Chunguang Guo

John R McWhirter

John Mcwhirter

Non-human animals (and/or non-human cells) and methods of using and making the same are provided, which non-human animals (and/or non-human cells) have a genome comprising human antibody-encoding sequences (i.e., immunoglobulin genes). Non-human animals described herein express antibodies that contain human Igλ light chains, in whole or in part. In particular, non-human animals provided herein are, in some embodiments, characterized by expression of antibodies that contain human Igλ light chains, in whole or in part, that are encoded by human Igλ light chain-encoding sequences inserted into an endogenous Igλ light chain locus of said non-human animals. Methods for producing antibodies from non-human animals are also provided.

Non-human animals having an engineered immunoglobulin lambda light chain locus

Provided herein are methods and compositions related to non-human animals that express exogenous Terminal Deoxynucleotidyltransferase (TdT).

Non-human animals expressing exogenous terminal deoxynucleotidyltransferase

Non-human animals (and/or non-human cells) and methods of using and making the same are provided, which non-human animals (and/or non-human cells) have a genome comprising human antibody-encoding sequences (i.e., immunoglobulin genes). Non-human animals described herein express antibodies that contain human Ig&#x3bb; light chains, in whole or in part. In particular, non-human animals provided herein are, in some embodiments, characterized by expression of antibodies that contain human Ig&#x3bb; light chains, in whole or in part, that are encoded by human Ig&#x3bb; light chain-encoding sequences inserted into an endogenous Ig&#x3bb; light chain locus of said non-human animals. Methods for producing antibodies from non-human animals are also provided.

Non-human animals having an engineered immunoglobulin &#x39b; light chain locus

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New York, NY, United States of America

Natasha Levenkova