University of Utah Research Foundation

Other

Natalya Y Rapoport

Glenn D Prestwich

William George Pitt

Russell Morris Condie

Kweon-Ho Nam

Described herein are nanoemulsions comprising (1) at least one fluoro ether and (2) a block copolymer comprising a hydrophilic block and hydrophobic block, wherein the nanoemulsion comprises a therapeutic agent in the nanoemulsion. The nanoemulsions are stable and are excellent drug delivery devices for ultrasound-mediated, image guided drug delivery. Also described herein are methods for using the nanoemulsions to treat tumors and cancers as well as using them as imaging agents.

Stable nanoemulsions for ultrasound-mediated drug delivery and imaging

Perfluorocarbon emulsions having a high stability and good oxygen release are disclosed and described. These perfluorocarbon emulsions are typically for use as artificial oxygen carriers. The perfluorocarbon emulsions include a disperse phase of a perfluorocarbon and an emulsion stabilizer, and continuous phase. The emulsion stabilizer can primarily include a poly(ethylene oxide) block copolymer. These stabilized perfluorocarbon emulsions can be used in liquid and/or hydrogel phases of perfusion bioreactors or various other culture systems to enhance cell viability in thick tissue constructs, or as blood substitutes, although other applications may also be considered.

Stable perfluorocarbon emulsion for use as an artificial oxygen carrier

Stabilization and acoustic activation of polymeric micelles for drug delivery

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Sandy, UT, United States of America

Natalya Y Rapoport