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Institut Organicheskoi Khimii Imeni N.d. Zelinskogo Akademii Nauk Sssr

Natalya Veniaminovna Kaverina

Irina Vitalievna Zaikonnikova

Arkady M Likhosherstov

Alexandr P Skoldinov

Ljudmila Ivanovna Suvorova

Irina Evgenievna Zimakova

Lia Vladimirovna Epishina

Oleg Vasilievich Lebedev

Lenor Ivanovich Khmelnitsky

Roman A Kamburg

Anatoly M Karpov

Lidia V Lapshina

Vladimir F Bogoyavlensky

Liya Semenovna Nazarova

Nikolai V Darinsky

Sergei S Novikov, Deceased

Arkady Mikhailovich Likhosherstov

Galina Alexandrovna Markova

Alexandr Petrovich Skoldinov

Dania A Valimukhametova

The anginal medicated compound according to the present invention comprises the active principle 2,4,6,8-tetramethyl-2,4,6,8-tetraazobicyclo-/3,3,0/-octanedione-3,7 of the formula: ##STR1## in combination with a pharmaceutical carrier. The medicated compound according to the present invention is useful for the treatment of patients suffering from ischemic heart disease.

Antianginal medicated compound

Novel compounds 10'-[.omega.-N/1,4-diazabicyclo(4,m,0)-alkanyl/-acyl] -phenothiazines having the formula: ##STR1## wherein X = H, Cl, CF.sub.3 ; n = 1, 2, 3; m = 3, 5; and their salts of acidic addition and quaternary salts. The process for producing said compounds comprises reacting .omega. -chloracyl -2-substituted phenothiazines with 1,4-diazabicyclo(4,m,0)-alkanes in an inert solvent medium at a temperature of 50-140.degree. C followed by isolation of the desired product. Said compounds are pharmacologically active. The most active compound 10'- [.beta.-N-/1,4-diazabicyclo-(4,3,0)-nonanyl/-propyonyl]-2'-chlorophenothia zine of the formula: ##STR2## is an active principle of a medicated compound possessing spasmolytic and coronary-dilatant effect.

10'-( .omega.-N)-1,4-Diazabicyclo(4,3,0)-alkanyl-lacyl) -phenothiazine

10'-[.omega.-N-/1,4-diazabicyclo (4,m,O)-alkanyl/-acyl]-Phenothiazines having the formula: ##STR1## wherein X=H, Cl, or CF.sub.3 ; n = 1, 2 or 3; and m = 3 or 5; and their pharmaceutically acceptable acidic addition and quaternary salts are pharmacologically active. The most active compound 10'[.beta.N-/1,4-diazabicyclo-(4,3,0)-nonanyl/-propionyl]-2'-chlorophenoth iazine of the formula: ##STR2## is useful as the active ingredient of a medicated compound possessing spasmolytic and coronary-dilatant effect. The process for producing said compounds comprises reacting an .omega.-chloracyl -2-substituted phenothiazine with a 1, 4-diazabicyclo-(4,m,O)-alaken in an inert solvent medium at a temperature of 50.degree.-140.degree. C followed by isolation of the desired product.

10'-[.omega.-N-/1,4-diazabicyclo(4,m,o)-alkanyl/-acyl]-phenothiazines,

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Moscow, Russia

Natalya Veniaminovna Kaverina