Gammadelta Therapeutics Ltd

King's College London

F-Star Therapeutics, Inc.

Natalie Mount

Adrian Hayday

Oliver Nussbaumer

Richard Woolf

Maria Luisa Iannitto

Mihriban Tuna

Richard Esmond Beatson

Mark Uden

Joshua Freedman

Richard Beatson

Shefali Bhumbra

Robert Good

Raj Jaysukhlal Mehta

The present invention provides methods of expanding γδ T cells from a non-haematopoietic tissue source. Further provided are compositions of expanded γδ T cells and methods of using the expanded γδ T cells (e.g., a part of an adoptive T cell therapy).

Expansion of γδ T cells, compositions, and methods of use thereof

The present invention provides multispecific antibodies comprising a Fab region and an Fc region, wherein the Fab region comprises a binding site specific for an epitope of the variable delta 1 (Vδ1) chain of a γδ T cell receptor (TCR); and the Fc region comprises an EGFR binding site. The present invention also provides compositions and pharmaceutical compositions comprising such multispecific antibodies, and method of making such multispecific antibodies. The present invention also provides methods of treatment and medical uses involving the multispecific antibodies.

Multispecific anti-TCR delta variable 1 antibodies

The present invention provides methods of expanding &#x3b3;&#x3b4; T cells from a non-haematopoietic tissue source. Further provided are compositions of expanded &#x3b3;&#x3b4; T cells and methods of using the expanded &#x3b3;&#x3b4; T cells (e.g., apart of an adoptive T cell therapy).

Expansion of &#x3b3;&#x3b4; T cells, compositions, and methods of use thereof

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London, United Kingdom

Natalie Mount