Virginia Tech Intellectual Properties Inc

Angiodynamics, Inc.

Natalie Beitel White

Rafael V Davalos

Christopher B Arena

Lucy Epshteyn

Suyashree Bhonsle

Melvin F Lorenzo

Irving Coy Allen

Nikolaos Dervisis

Electroporation-based therapies (EBTs) employ high voltage pulsed electric fields (PEFs) to permeabilize tumor tissue, resulting in changes in passive electrical properties detectable using electrical impedance spectroscopy (EIS). Currently, commercial potentiostats for EIS are limited by impedance spectrum acquisition time (˜10 s); this timeframe is much larger than pulse periods used with EBTs (˜1 s). Fourier Analysis SpecTroscopy (FAST) is introduced as a methodology for monitoring tissue inter-burst impedance (diagnostic FAST) and intra-burst impedance (therapeutic FAST) during EBTs. FAST is a rapid-capture (<<1 s) technique which enables monitoring of inter-burst and intra-burst impedance during EBTs in real-time. FAST identified a frequency which delineates thermal effects from electroporation effects in measured impedance. Significance: FAST demonstrates the potential to perform EIS, in addition to intra-burst impedance spectroscopy, using existing pulse generator topologies.

Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies

Described herein are methods and systems of performing immunotherapy on a subject and/or determining if a subject will be responsive to ablation immunotherapy.

Treatment planning system for immunotherapy enhancement via non-thermal ablation

Described herein are methods of performing immunotherapy on a subject and/or determining if a subject will be responsive to ablation immunotherapy.

Treatment planning for immunotherapy based treatments using non-thermal ablation techniques

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Christianburg, VA, United States of America

Natalie Beitel White