Ohio State Innovation Foundation

Natalia Higuita-Castro

Daniel Gallego-Perez

Chandan K Sen

Lingqian Chang

William D Carson

Silvia M Duarte Sanmiguel

Samir Ghadiali

Joshua Englert

Provided herein are devices and methods for topically and controllably delivering cargo or collecting samples into or from biological tissues, particularly the skin. These devices permit delivery of cargo and collection of samples from cell layers deep within a tissue. These devices include microstructure arrays comprising nanochannels. Also disclosed is a device comprising a one or more microstructure arrays encased in a frame.

Interpenetrating microstructures for nanochannel-based sampling and/or cargo delivery

Disclosed herein is a method of 'reprogramming' highly motile cells found in tumors, such as these highly motile GSC and/or MDSC clones, into “auto-destructive” cell “missiles” (referred to herein as therapeutic stealth cells) that can seek and destroy new foci of recurrence within the body, such as the brain. Cells with enhanced motility can be sorted out from heterogeneous populations and then be rendered “auto-destructive” by deterministic delivery of an anti-cancer agent, such as an oncolytic virus plasmid cocktail.

Nano-engineered therapeutic stealth cells

Disclosed are lung-targeted extracellular vesicles (EVs) loaded with an anti-inflammatory cargo, as well as compositions, systems, and methods for making same. The disclosed EVs can contain a lung targeted ligand, such as a fusion protein containing a lung targeting moiety. Also disclosed is a composition comprising an EV containing the disclosed fusion protein. In some embodiments, the EV is loaded with an anti-inflammatory cargo. Also disclosed is an EV-producing cell engineered to produce the disclosed EVs. Also disclosed is a method for making the disclosed EVs that involves culturing the disclosed EV-producing cells under conditions suitable to produce EVs.

Nanocarriers for lung inflammation therapy

Provided herein are devices and methods for topically and controllably delivering cargo across or into biological tissues, particularly the skin. These devices permit delivery of cargo to deeper cell layers of a tissue. These devices include microstructure arrays comprising nanochannels. Also disclosed is a device comprising a one or more microstructure arrays encased in a frame.

Growing community of inventors

Columbus, OH, United States of America

Natalia Higuita-Castro