Northwestern University

Exicure, Inc.

Natalia Chernyak

Chad A Mirkin

Sergei M Gryaznov

SonBinh T Nguyen

Aleksandar Filip Radovic-Moreno

Christopher C Mader

Resham Singh Banga

Sonbinh T Nguyen

Sergei Gryaznov

Christopher Mader

Aleksandar Radovic-Moreno

Liposomes termed as small unilamellar vesicles (SUVs), can be synthesized in the 20-50 nm size range, but encounter challenges such as instability and aggregation leading to inter-particle fusion. This limits their use as a therapeutic delivery agent. Increasing the surface negative charge of SUVs, via the attachment of anionic entities such as DNA/RNA, increases the colloidal stability of these vesicles. Additionally, the dense spherical arrangement and radial orientation of nucleic acids exhibits unique chemical and biological properties, unlike their linear counterparts. These liposomal particles, are non-toxic and though anionic, can efficiently enter cells without the aid of ancillary cationic transfection agents in a non-immunogenic fashion. These exceptional properties allow their use as delivery agents for gene regulation in different therapies and offer an alternative platform to metal core spherical nucleic acids.

Liposomal particles, methods of making same and uses thereof

Growing community of inventors

Evanston, IL, United States of America

Natalia Chernyak