Transmural Systems LLC

Medtronic Vascular, Inc.

National Institutes of Health, a Component of the US Dept. of Health & Human Services

Kips Bay Medical, Inc.

Medtronic, Inc.

Medtronic Ave, Inc.

Neograft Technologies, Inc.

Other

C. R. Bard, Inc.

Henry Ford Health System

National Institutes of Health (nih)

Telltale, Incorporated

Vascular Graft Colutions Ltd.

The United States of America, As Represented by the Secretary, Department of Health and Human Service

Kocaturk, Ozgur

Nasser Rafiee

Matthew Rust

Carol Elsa Eberhardt

Nareak Douk

Stuart MacDonald

Koosha Rafiee

Peter Paul Zilla

Deon Bezuidenhout

Mark Yeoman

Thomas Franz

Morgan House

Michael F Wolf

Hellmut C Bowles

Rany Busold

Robert J Lederman

Peter Strickler

Eliot F Bloom

Paul Human

Toby Rogers

David S Brin

Rany Huynh

Juan-Pablo Mas

Ozgur Kocaturk

Philipp Bonhoeffer

Peter A Lunn

Jerry Brightbill

Albert Harold Dunfee

Jeffrey Kapec

Kazuna Tanaka

Joseph C Morrow

Jerald Lamont Redmond

James F Crittenden

Dennis L Brooks

Robert D Lashinski

Ronald B Lamport

Dustin Thompson

Alexander J Hill

Walter Bruszewski

Janice Lynn Shay

David Barone

Michael S Noone

John B Horrigan

Donald M Golden

William W O'Neill

Jonathan Morris

Douglas A Fogg

David R Erickson

Mark J Capps

Biwei MacDonald

Patricia O'Beirne

Alana Rafiee

Alexis Balcom

Mai Le Diep

Michael Finney

Kanishka Ratnayaka

Steven Dapolito

Charles Daugherty

Stuart Mac Donald

Prema Ganesan

Curtis Hanson

D H Perkins

Bruce Adams

Stuart R MacDonald

James Machek

Harold M Aznoian

Jia Hua Xiao

Thomas E Watson

Matthew S Poole

Adam Stephens

Adam Brett Greenbaum

David J Lentz

Gian Pellegrini

Peggy Grills

Sonny Yamasaki

Barbara DeVaux

Matt S Poole

Ellen M Jennings

Timothy P Collins

Heng Mao

Steve Dapolito

David J Sauvageau

Jaffar Khan

Ahmed Malek

Michael C Wolf

Peter G Strickler

Paul D Gillette

G Randall Green

Adam Groothuis

Christopher G Bruce

Jaffar M Khan

Dursun Korel Yildirim

Helmut Bowles

Narenk Douk

Rany Huynh Busold

Stuart R Macdonald

Morgan M House

The present disclosure relates to novel and advantageous systems and methods for deploying a surgical tool or guidewire. Particularly, the present disclosure relates to novel and advantageous systems and methods for deploying a surgical tool for use in changing the shape of portions of luminal systems. More particularly, the present disclosure relates to novel and advantageous systems and methods including an access catheter to direct an implement, such as a guide wire, off axis into a wall of a vessel or a wall of a tissue structure.

Access catheter

The disclosure provides various embodiments of catheters having articulable ends that can be used for various procedures. Embodiments of methods are also provided that can be performed with catheters in accordance with the present disclosure.

Tissue excision, cutting, and removal systems and methods

Exemplary embodiments provide methods and systems for delivering a prosthesis to a target location in a lumenal system of a patient. At least one tether is secured proximate the target location to serve as a rail, and a prosthesis is advanced along the rail to the target location and secured in place. Exemplary methods and systems provide for repair of the mitral and tricuspid valves, as well as abdominal aortic aneurysms, stomach valves, fallopian tubes and the pulmonary system, among others. Also disclosed are various prostheses suitable for use with the disclosed methods and systems.

Methods and systems for delivering prostheses using rail techniques

The disclosure provides various embodiments of systems to facilitate the cutting of tissue structures and other tissue structures percutaneously.

Catheter and actuator systems and methods

The disclosure provides various embodiments of prostheses and delivery systems to permit an interventional cardiologist to create shunts between various blood vessels. Moreover, the disclosed shunts can be used to shunt between various hollow organs, as set forth in the present disclosure.

Percutaneous shunt devices and related methods

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve and/or tricuspid valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation as well as tricuspid regurgitation. The disclosure also provides improved techniques for cardiac pacing.

Cardiac annuloplasty procedures, related devices and methods

Catheters and manipulators with articulable ends

The disclosure provides valve prostheses and methods of installation. One embodiment of the prosthesis has a generally tubular body adapted for placement proximate a mitral annulus. The tubular body has a generally tubular upper portion adapted to substantially reside in the left atrium above the mitral annulus. The generally tubular upper portion has a first circumferential wall that is outwardly biased to urge against cardiac tissue of the left atrium. The tubular body also includes a lower portion extending downwardly from the generally tubular upper portion, the lower portion being configured to substantially reside in the left ventricle below the mitral annulus. The lower portion of this embodiment can be defined by an generally circumferential wall that extends downwardly from the generally tubular upper portion. The generally circumferential wall has a first circumferential end and a second circumferential end, and defines a circumferential extent therebetween.

Devices, systems and methods for repairing lumenal systems

In accordance with the disclosure, devices are provided for closing an opening in tissue. The devices include a proximal portion configured and arranged to occlude the tissue opening, and a distal anchor portion configured and arranged to anchor the device in the tissue opening. If desired, the distal anchor portion can be moved proximally or distally with respect to the proximal portion during implantation. The proximal portion can be configured and arranged to fit into a left atrial appendage of a patient, and further wherein the distal anchor portion is configured and arranged to extend into the left atrial appendage.

Devices and methods for closing openings in tissue structures

Devices and methods are disclosed for the treatment or repair of regurgitant cardiac valves, such as a mitral valve. An illustrative annuloplasty device can be placed in the coronary sinus to reshape the mitral valve and reduce mitral valve regurgitation. The disclosure also provides improved techniques for cardiac pacing.

Annuloplasty procedures, related devices and methods

The disclosure provides various embodiments of catheters that can be used for various procedures. Embodiments of methods are also provided that can be performed with catheters in accordance with the present disclosure.

In some implementations, a radially self-expanding endograft prosthesis is provided that includes (i) distal flange that is self-expanding and configured to flip generally perpendicularly with respect to a body of the prosthesis to help seat the prosthesis against a tissue wall, (ii) a distal segment extending proximally from the distal flange that has sufficient stiffness to maintain a puncture open that is formed through a vessel wall (iii) a compliant middle segment extending proximally from the distal segment, the middle segment being more compliant than the distal segment, and having independently movable undulating strut rings attached to a tubular fabric, the combined structure providing flexibility and compliance to allow for full patency while flexed, the segment being configured to accommodate up to a 90 degree bend, (iv) a proximal segment having a plurality of adjacent undulating strut rings that are connected to each other.

Devices and methods for effectuating percutaneous shunt procedures

The disclosure provides systems and related methods for delivering a prosthesis to a target location. Various embodiments of useful valve prostheses are also disclosed.

The present disclosure provides medical devices having MRI-compatible circuitry. Preferably, the devices do not project an enlarged profile, yet their position can be determined during an iMRI procedure. Illustrative embodiments of such a device can include a base surface, a first conducting layer disposed on the base surface, a first insulating layer disposed over at least a portion of the first conducting layer, and a second conducting layer disposed over at least a portion of the first insulating layer.

MRI-compatible devices

Growing community of inventors

Andover, MA, United States of America

Nasser Rafiee