Other

Gulak, Patrick Glenn

Maxwell, Karen Lee

Nikkhoo, Nasim

Man, Cintia Po Sze

Nasim Nikkhoo

Karen Maxwell

Glenn Gulak

Cintia Po Sze Man

Patrick Glenn Gulak

Karen Lee Maxwell

Cintia Po Man

Disclosed are methods and systems for the detection of bacteria in a sample. The methods comprises contacting the sample with an antibacterial agent and a bacteria identification sensor, and involves the permeabilization of the bacteria by the antibacterial agent, and the subsequent detection of an efflux of potassium ions using a bacteria identification sensor comprising a potassium-sensitive ISFET. Also disclosed are bacteria identification sensor comprising a potassium-sensitive ISFET useful in the practice of the disclosed methods.

Integrated sensor for the rapid identification of bacteria using ISFETS

A sensor for detecting an electric field fluctuation associated with the permeabilization of a bacterial cell wall comprises a substrate, at least two electrodes integrated on the substrate, an amplifier integrated on the substrate, and a processor electrically connected to the amplifier to analyze the amplified signal. The substrate and the at least two electrodes define a well between the at least two electrodes, and the at least two electrodes being configured to generate a signal in response to an electric field fluctuation in close proximity to the well or the electrodes triggered when at least one antibacterial agent associated with the well contacts a cognate target. The amplifier is configured to generate an amplified signal in response to the signal. In addition, the processor is electrically connected to the amplifier to analyze the amplified signal.

Method and apparatus for detecting an electric field fluctuation associated with the permeabilization of a bacterial cell wall

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Toronto, Canada

Nasim Nikkhoo