Nec Corporation

Tanita Corporation

Provigate Inc.

National Institute of Advanced Industrial Science and Technology

Keio University

Narushi Ito

Norikazu Katayama

Toru Matsumoto

Akio Ohashi

Mitsumi Nishi

Yuuya Miyazawa

Jun Kimura

Kenji Yokoyama

Yasuyoshi Matsumoto

Hirotaka Minagawa

Tsunenori Arai

Shinya Nakamoto

Soichi Saito

Yoshiyuki Yanagimoto

Masako Furusawa

Yuki Kawase

Yasunobu Oka

Masayuki Mizushina

Hiroki Tsuruta

Yohei Inaba

Yoshie Kawana

A sensor chip (), to be brought close to an organism to collect a body fluid in order to chemically measure the body fluid, is configured such that a surface () to be brought close to the organism is curved.

Sensor chip, sensing apparatus, cover, body fluid collection device, and sensor

The objective of the present invention is to provide a liquid sample collector capable of collecting a trace amount of a specimen such as a tear safely and in an adequate amount. This trace amount liquid sample collector is characterized in that: the liquid sample collector is provided with a main body and a first absorbent body; the main body has at least one open end portion; the main body includes a hydrophobic material having elasticity; the first absorbent body is disposed at least partially inside the main body; the first absorbent body includes a water-absorbent material; and the first absorbent body is disposed in such a way as to be capable of coming into contact with the outside by way of the at least one open end portion of the main body.

Trace amount liquid sample collector

Provided is a glycated protein sensor provided with: immobilized protease; immobilized ketoamine oxidase; and a hydrogen peroxide detection section.

Glycated protein sensor, measurement method, program, and sensor manufacture method

Aimed at readily and exactly separate 8-hydroxy-2'-deoxyguanosine (8-OHdG) contained in a sample, a column packing material used for separating 8-OHdG, which contains a packing material composed of a material having a straight-chain hydrocarbon group having 6 or more and 30 or less carbon atoms as a functional group, and having a carbon content over the surface of carrier of 18% or less by element ratio, wherein the packing material contains 1 cumulative percent or more and 20 cumulative percent or less, on the particle-count basis, of particles having a circle-equivalent diameter, measured using a flow-type particle image analyzer, of 0.5 &#x3bc;m or larger and 10 &#x3bc;m or smaller, is used.

Column packing material, column using the same, and method of separation using the same

A device and method for optically measuring a substance in blood using the nail as an optical window are provided. A device for optically measuring a test substance in blood by using the nail as an optical window and correcting or eliminating fluctuation of a measurement value based on optical characteristics of the nail plate, comprising irradiation means applying light within a wavelength range for measuring absorption by the test substance to the nail of a subject, detection means detecting light diffused/reflected from or transmitted through the body of the subject, and processing means processing a signal obtained by the detection means to convert the signal into a concentration of the test substance.

Noninvasive measuring device for substance in blood via nail and a nail evaporation device

There is disclosed means for quickly solving instability of sensor sensitivity performances found in an initial stage and stabilizing the sensor sensitivity performances, when immersing a chemical sensor kept under a dry state in a buffer solution used as a storage liquid and applying a measurement bias between a working electrode and a reference electrode to make first use of the chemical sensor for measurement in which the chemical sensor is used. To make the first use of the chemical sensor, after immersing the chemical sensor kept under a dry state in the buffer solution used as the storage liquid, a first initial treatment bias having the same direction as that of the measurement bias and possessing an absolute value larger than that of the measurement bias is applied between the working electrode and the reference electrode for a first initial treatment time. Subsequently, the bias is changed to a second initial treatment bias which is the same as the measurement bias, and the second initial treatment bias is applied for a second initial treatment time. When such a two-step initial treatment operation is carried out, the stabilized sensor sensitivity performance is achieved.

Method for measuring by means of chemical sensor, and chemical sensor type measuring apparatus

A system for providing a home health care service includes a health care center, a service recipient device, and the Internet that connects these components. The health care center: is constructed on the Internet; includes a database for registering personal data that are necessary for the health care of registered at-home patients as basic health care data and storing measurement data that are provided from at-home patients over the course of time; and has the functions of inferring the health conditions of at-home patients based on the measurement data and the basic health care data, and offering appropriate services necessary for inferred health conditions. The service recipient device includes a biosensor and a signal processor. The biosensor detects chemical components contained in a substance that is discharged from the human body and converts detected values to electrical signals at the point of discharge.

Method of providing a home health care service and system for providing a home health care service

A system for providing a home health care service includes a health care center, a service recipient device, and the Internet that connects these components. The health care center: is constructed on the Internet; includes a database for registering personal data that are necessary for the health care of registered at-home patients as basic health care data and storing measurement data that are provided from at-home patients over the course of time; and has the functions of inferring the health conditions of at-home patients based on the measurement data as well as the basic health care data and offering services necessary for health care or services appropriate for inferred health conditions, to at-home patients. The service recipient device includes a biosensor and a signal processor. The biosensor detects chemical components contained in a substance that is discharged from the human body and converts detected values to electrical signals at the point of discharge. The signal processor performs processing of the output of the biosensor to automatically generate measurement data and transmits the measurement data to the health care center by way of the Internet. Chosen Drawing: FIG. 5

A corneum puncture needle for extracting tissue fluid from under the skin corneum includes a needle body and a stylus extending from the needle body to be inserted into a corneum of a human body. The stylus and the needle body form therebetween a stepped portion acting as a stopper when the stylus is inserted into a corneum of a human body. The needle body has a core formed in a unitary body with the stylus and a coating layer or a tube formed on the core. The stylus has a suitable length for prevention of damage of blood vessel. A plurality of puncture needles may be arranged on a holder.

Corneum puncture needle

A device for taking up a fluid present on a flexible surface includes a support member and a fluid-passage member; the support member includes an opening portion having an end surface defining an abutment surface adapted to be held in abutment with the flexible surface; the fluid-passage member includes an aperture and is disposed within the opening portion of the support member; the fluid-passage member has an opening end defining an inlet, and is constructed to permit the fluid to flow thereinto by capillarity; the opening end having an end face is disposed inside with respect to the abutment surface of the support member and is positioned such that, when the abutment surface of the support member is brought into abutment with the flexible surface, only the fluid present thereon is brought into contact with the end face.

Device for taking up fluid

A drop in measurement accuracy of biosensors, due to interferents in a measurement sample is avoided by an arrangement wherein: a hydrogen peroxide electrode 2 is formed on an insulated base 1, and then a .gamma.-aminopropyltriethoxysilane film 3, an acetylcellulose film 4, a perfluorocarbonsulfonic acid resin film 5, an organic macromolecular film 6 incorporating an immobilized enzyme with catalytic properties, and a polyalkylsiloxane film 7, are sequentially formed on the electrode 2.

Biosensor

A biosensor is provided with a memory for storing data including a data and a time of fabricating the biosensor, a lot number of the biosensor, an effective period of the biosensor, the biosensor characteristics, and administrative data of the biosensor. The memory may store additional data such as the measured date, the consecutive (total) measuring time, the measured results, etc.

Biosensor with a data memory

Pretreatment of eliminating stratum corneum form the skin for non-invasive measurement of biomedical substances in blood has been improved as to time required, pain to man for test, stability of extraction and invasion to the skin, by introducing chemical and/or steam-spraying treatment(s) of the skin to swell and/or decompose keratinized cells and/or an adhesive strength detector to monitor the elimination level.

Method of eliminating stratum corneum from the skin and an instrument to

A biosensor includes an elastic substrate, a sensor tip, and a piezoelectric actuator. The sensor tip is mounted on one end of the substrate. The piezoelectric actuator is provided on the other end of the substrate.

Biosensor device provided with an agitator

An electrochemical sensor wherein a FET for measuring chemical substances and a reference electrode are covered with a continuous hydrous polymer on an insulating substrate, and on the hydrous polymer, an enzyme-immobilized film is formed in a region positioned on a channel part of FET for measuring chemical substances.

Growing community of inventors

Tokyo, Japan

Narushi Ito